Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Antigen receptor genes and the evolution of a recombinase.

Literature DB >> 15522623

Antigen receptor genes and the evolution of a recombinase.

Abstract

Antigen receptor genes exist in the germline in a "split" configuration and are assembled in developing B and T lymphocytes by V(D)J recombination. This site-specific recombination reaction is initiated by a complex containing the RAG1 and RAG2 proteins and completed by general DNA repair factors. RAG1 and RAG2, like the adaptive immune system itself, are found exclusively in jawed vertebrates, and are thought to have entered the vertebrate genome by horizontal transmission as components of a transposable element. This review discusses the structure of antigen receptor genes and the mechanisms by which they are assembled and diversified, and then goes on to consider the evolutionary implications of the arrival of the hypothetical "RAG transposon".

Entities: Species

Mesh：

Substances：

Year: 2004 PMID： 15522623 DOI： 10.1016/j.smim.2004.08.004

Source DB: PubMed Journal: Semin Immunol ISSN： 1044-5323 Impact factor: 11.130

Keyword Cloud
Cited

29 in total

1. Ancient phylogenetic beginnings of immunoglobulin hypermutation.

Authors: Jaroslav Kubrycht; Karel Sigler; Michal Růzicka; Pavel Soucek; Jirí Borecký; Petr Jezek
Journal: J Mol Evol Date: 2006-10-06 Impact factor: 2.395

2. Molluscan mobile elements similar to the vertebrate Recombination-Activating Genes.

Authors: Yuri Panchin; Leonid L Moroz
Journal: Biochem Biophys Res Commun Date: 2008-02-29 Impact factor: 3.575

3. Identification of flap structure-specific endonuclease 1 as a factor involved in long-term memory formation of aversive learning.

Authors: Lorena Saavedra-Rodríguez; Adrinel Vázquez; Humberto G Ortiz-Zuazaga; Nataliya E Chorna; Fernando A González; Lissette Andrés; Karen Rodríguez; Fernando Ramírez; Alan Rodríguez; Sandra Peña de Ortiz
Journal: J Neurosci Date: 2009-05-06 Impact factor: 6.167

Review 4. Evolutionary and functional relationships of B cells from fish and mammals: insights into their novel roles in phagocytosis and presentation of particulate antigen.

Authors: J Oriol Sunyer
Journal: Infect Disord Drug Targets Date: 2012-06

Antigen receptor genes and the evolution of a recombinase.

1. Ancient phylogenetic beginnings of immunoglobulin hypermutation.

2. Molluscan mobile elements similar to the vertebrate Recombination-Activating Genes.

3. Identification of flap structure-specific endonuclease 1 as a factor involved in long-term memory formation of aversive learning.

Review 4. Evolutionary and functional relationships of B cells from fish and mammals: insights into their novel roles in phagocytosis and presentation of particulate antigen.

Review 5. Evolution of adaptive immunity from transposable elements combined with innate immune systems.

Review 6. The origins of the Rag genes--from transposition to V(D)J recombination.

Review 7. Structure and function of the non-classical major histocompatibility complex molecule MR1.

8. Regulation of antigen-receptor gene assembly in hagfish.

Review 9. Mechanisms controlling expression of the RAG locus during lymphocyte development.

Review 10. Opportunities to exploit non-neutralizing HIV-specific antibody activity.