AIMS: Incomplete excision leads to local recurrence following breast conservation therapy (BCT). The aim of this study was to examine factors associated with cavity margin (CM) positivity and return to theatre rates. METHODS: Breast conservation surgery with entire CM excision was the initial procedure in 301 patients with 303 breast cancers. Of these, 258 patients were treated successfully with breast conservation surgery and 43 patients subsequently required a mastectomy for persistent involved margins. The mean and median follow-up was 38 and 42 (range 6-78) months, respectively. RESULTS: Positive CMs were found in 73 out of 303 tumours. Large tumour size (p<0.001) and tumour type (invasive lobular cancer and ductal carcinoma in-situ) (p=0.043) were significant predictors of CM positivity both by univariate and multivariate analysis. As a result of CM status in relation to initial margin (IM) status, 60 cancers treated that were IM positive but CM negative avoided return for further excision at a second operative procedure. CONCLUSION: Complete CM excision should avoid the need for further re-excision surgery in most patients where initial specimen margin was positive.
AIMS: Incomplete excision leads to local recurrence following breast conservation therapy (BCT). The aim of this study was to examine factors associated with cavity margin (CM) positivity and return to theatre rates. METHODS: Breast conservation surgery with entire CM excision was the initial procedure in 301 patients with 303 breast cancers. Of these, 258 patients were treated successfully with breast conservation surgery and 43 patients subsequently required a mastectomy for persistent involved margins. The mean and median follow-up was 38 and 42 (range 6-78) months, respectively. RESULTS: Positive CMs were found in 73 out of 303 tumours. Large tumour size (p<0.001) and tumour type (invasive lobular cancer and ductal carcinoma in-situ) (p=0.043) were significant predictors of CM positivity both by univariate and multivariate analysis. As a result of CM status in relation to initial margin (IM) status, 60 cancers treated that were IM positive but CM negative avoided return for further excision at a second operative procedure. CONCLUSION: Complete CM excision should avoid the need for further re-excision surgery in most patients where initial specimen margin was positive.
Authors: L O'Connell; S Walsh; D Evoy; A O'Doherty; C Quinn; J Rothwell; J Geraghty; E W McDermott; R Prichard Journal: Ann R Coll Surg Engl Date: 2019-03-11 Impact factor: 1.891
Authors: Roshani R Patel; Tianyu Li; Eric A Ross; Linda Sesa; Elin R Sigurdson; Richard J Bleicher Journal: Ann Surg Oncol Date: 2010-06-12 Impact factor: 5.344
Authors: Benjamin St Peter; Sigfrid Yngvesson; Paul Siqueira; Patrick Kelly; Ashraf Khan; Stephen Glick; Andrew Karellas Journal: IEEE J Biomed Health Inform Date: 2013-07 Impact factor: 5.772
Authors: Lee G Wilke; J Quincy Brown; Torre M Bydlon; Stephanie A Kennedy; Lisa M Richards; Marlee K Junker; Jennifer Gallagher; William T Barry; Joseph Geradts; Nimmi Ramanujam Journal: Am J Surg Date: 2009-10 Impact factor: 2.565
Authors: Alice K Fortune-Greeley; Stephanie B Wheeler; Anne-Marie Meyer; Katherine E Reeder-Hayes; Andrea K Biddle; Hyman B Muss; William R Carpenter Journal: Breast Cancer Res Treat Date: 2013-12-04 Impact factor: 4.872