Literature DB >> 15520852

Tregs in T cell vaccination: exploring the regulation of regulation.

Irun R Cohen1, Francisco J Quintana, Avishai Mimran.   

Abstract

T cell vaccination (TCV) activates Tregs of 2 kinds: anti-idiotypic (anti-id) and anti-ergotypic (anti-erg). These regulators furnish a useful view of the physiology of T cell regulation of the immune response. Anti-id Tregs recognize specific effector clones by their unique TCR CDR3 peptides; anti-id networks of CD4+ and CD8+ Tregs have been described in detail. Here we shall focus on anti-erg T regulators. Anti-erg T cells, unlike anti-id T cells, do not recognize the clonal identity of effector T cells; rather, anti-erg T cells recognize the state of activation of target effector T cells, irrespective of their TCR specificity. We consider several features of anti-erg T cells: their ontogeny, subset markers, and target ergotope molecules; mechanisms by which they regulate other T cells; mechanisms by which they get regulated; and therapeutic prospects for anti-erg upregulation and downregulation.

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Year:  2004        PMID： 15520852      PMCID： PMC524317          DOI： 10.1172/JCI23396

Source DB:  PubMed          Journal:  J Clin Invest        ISSN： 0021-9738            Impact factor:   14.808


  39 in total

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Journal:  Eur J Immunol       Date:  1990-10       Impact factor: 5.532

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Journal:  Nature       Date:  1989-10-12       Impact factor: 49.962

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Journal:  Science       Date:  1989-05-19       Impact factor: 47.728

5.  Anti-idiotypic network induced by T cell vaccination against experimental autoimmune encephalomyelitis.

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Journal:  Nature       Date:  1981-07-02       Impact factor: 49.962

Review 10.  The IL-2/IL-2 receptor system: a target for rational immune intervention.

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  20 in total

Review 1.  An integrated view of suppressor T cell subsets in immunoregulation.

Authors:  Hong Jiang; Leonard Chess
Journal:  J Clin Invest       Date:  2004-11       Impact factor: 14.808

2.  Heat shock protein 60 enhances CD4+ CD25+ regulatory T cell function via innate TLR2 signaling.

Authors:  Alexandra Zanin-Zhorov; Liora Cahalon; Guy Tal; Raanan Margalit; Ofer Lider; Irun R Cohen
Journal:  J Clin Invest       Date:  2006-06-08       Impact factor: 14.808

3.  Hsp70 expression and induction as a readout for detection of immune modulatory components in food.

Authors:  Lotte Wieten; Ruurd van der Zee; Renske Goedemans; Jeroen Sijtsma; Mauro Serafini; Nicolette H Lubsen; Willem van Eden; Femke Broere
Journal:  Cell Stress Chaperones       Date:  2009-05-27       Impact factor: 3.667

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Authors:  K Thümmler; A Ramming; H Schulze-Koops; A Skapenko
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5.  The specificity of T cell regulation that enables self-nonself discrimination in the periphery.

Authors:  Yilun Wu; Zongyu Zheng; Yihua Jiang; Leonard Chess; Hong Jiang
Journal:  Proc Natl Acad Sci U S A       Date:  2008-12-31       Impact factor: 11.205

Review 6.  The nervous and the immune systems: conspicuous physiological analogies.

Authors:  Julio Sotelo
Journal:  J Comp Physiol A Neuroethol Sens Neural Behav Physiol       Date:  2014-11-15       Impact factor: 1.836

Review 7.  Vaccines against myasthenia gravis.

Authors:  Sonia Berrih-Aknin; Sara Fuchs; Miriam C Souroujon
Journal:  Expert Opin Biol Ther       Date:  2005-07       Impact factor: 4.388

8.  Therapeutic effect of ergotope peptides on CIA by down-regulation of inflammatory and Th1/Th17 responses and induction of regulatory T cells.

Authors:  Xiaoyin Niu; Shaohua Deng; Shan Li; Yebin Xi; Chengzhen Li; Li Wang; Dongyi He; Zhaojun Wang; Guangjie Chen
Journal:  Mol Med       Date:  2016-08-30       Impact factor: 6.354

9.  CD4+ regulatory T cell responses induced by T cell vaccination in patients with multiple sclerosis.

Authors:  Jian Hong; Ying C Q Zang; Hong Nie; Jingwu Z Zhang
Journal:  Proc Natl Acad Sci U S A       Date:  2006-03-17       Impact factor: 11.205

10.  HSP60 as a target of anti-ergotypic regulatory T cells.

Authors:  Francisco J Quintana; Avishai Mimran; Pnina Carmi; Felix Mor; Irun R Cohen
Journal:  PLoS One       Date:  2008-12-24       Impact factor: 3.240
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