Literature DB >> 15517000

A-type lamins: guardians of the soma?

Chris J Hutchison1, Howard J Worman.   

Abstract

The gene LMNA encodes the proteins lamins A and C and is implicated in nine different laminopathies - inherited diseases that are linked to premature ageing. Recent evidence has demonstrated that lamins A and C have essential functions in protecting cells from physical damage, as well as in maintaining the function of transcription factors required for the differentiation of adult stem cells. Thus, the degenerative nature of laminopathies is explained because these lamins are essential for maintenance of somatic tissues in adulthood.

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Year:  2004        PMID： 15517000     DOI： 10.1038/ncb1104-1062

Source DB:  PubMed          Journal:  Nat Cell Biol        ISSN： 1465-7392            Impact factor:   28.824


  65 in total

1.  The role of Lamin A in cytoskeleton organization in colorectal cancer cells: a proteomic investigation.

Authors:  Clare R Foster; Joanne L Robson; William J Simon; Jeremy Twigg; Derek Cruikshank; Robert G Wilson; Chris J Hutchison
Journal:  Nucleus       Date:  2011-09-01       Impact factor: 4.197

2.  Nuclear envelope proteins Nesprin2 and LaminA regulate proliferation and apoptosis of vascular endothelial cells in response to shear stress.

Authors:  Yue Han; Lu Wang; Qing-Ping Yao; Ping Zhang; Bo Liu; Guo-Liang Wang; Bao-Rong Shen; Binbin Cheng; Yingxiao Wang; Zong-Lai Jiang; Ying-Xin Qi
Journal:  Biochim Biophys Acta       Date:  2015-02-23

3.  Tight skin and limited joint movements as early presentation of Hutchinson-Gilford progeria in a 7-week-old infant.

Authors:  Lieve Sevenants; Carine Wouters; Annachiara De Sandre-Giovannoli; Hugo Devlieger; Koen Devriendt; Joost J van den Oord; Karel Marien; Nicolas Lévy; Marie-Anne Morren
Journal:  Eur J Pediatr       Date:  2005-02-22       Impact factor: 3.183

Review 4.  The genome and the nucleus: a marriage made by evolution. Genome organisation and nuclear architecture.

Authors:  Helen A Foster; Joanna M Bridger
Journal:  Chromosoma       Date:  2005-10-15       Impact factor: 4.316

Review 5.  A-type lamin complexes and regenerative potential: a step towards understanding laminopathic diseases?

Authors:  Josef Gotzmann; Roland Foisner
Journal:  Histochem Cell Biol       Date:  2005-09-02       Impact factor: 4.304

Review 6.  Laminopathies: multiple disorders arising from defects in nuclear architecture.

Authors:  Veena K Parnaik; Kaliyaperumal Manju
Journal:  J Biosci       Date:  2006-09       Impact factor: 1.826

7.  Mislocalization of prelamin A Tyr646Phe mutant to the nuclear pore complex in human embryonic kidney 293 cells.

Authors:  Yong Pan; Abhimanyu Garg; Anil K Agarwal
Journal:  Biochem Biophys Res Commun       Date:  2007-01-31       Impact factor: 3.575

Review 8.  Nuclear mechanics in disease.

Authors:  Monika Zwerger; Chin Yee Ho; Jan Lammerding
Journal:  Annu Rev Biomed Eng       Date:  2011-08-15       Impact factor: 9.590

9.  The laminated hearts.

Authors:  Friedrich C Luft
Journal:  J Mol Med (Berl)       Date:  2008-01-15       Impact factor: 4.599

Review 10.  The role of lamin A/C in mesenchymal stem cell differentiation.

Authors:  Bo Zhang; Yang Yang; Reziwan Keyimu; Jin Hao; Zhihe Zhao; Rui Ye
Journal:  J Physiol Biochem       Date:  2019-01-31       Impact factor: 4.158
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