Literature DB >> 15508112

Gene therapy for immunodeficiency diseases.

Alain Fischer1, Salima Hacein-Bey-Abina, Marina Cavazzana-Calvo.   

Abstract

Primary immunodeficiency diseases represent good targets for hematopoietic stem cell-targeted gene therapy. Severe combined immunodeficiencies (SCID) have been the first examples of successful gene therapy based on the ex vivo usage of retroviral vectors. New advances in the technology of gene transfer should further promote gene therapy as a safe and effective therapeutic strategy of immunodeficiency diseases.

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Year:  2004        PMID: 15508112     DOI: 10.1053/j.seminhematol.2004.07.003

Source DB:  PubMed          Journal:  Semin Hematol        ISSN: 0037-1963            Impact factor:   3.851


  2 in total

Review 1.  Stem cells and genetic disease.

Authors:  A Mackay-Sim; P Silburn
Journal:  Cell Prolif       Date:  2008-02       Impact factor: 6.831

Review 2.  Chromatin tethering and retroviral integration: recent discoveries and parallels with DNA viruses.

Authors:  Anne M Meehan; Eric M Poeschla
Journal:  Biochim Biophys Acta       Date:  2009-10-15
  2 in total

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