| Literature DB >> 15507715 |
Masato Ikeda1, Richard Longnecker.
Abstract
Latent membrane protein 2A (LMP-2A) of Epstein-Barr virus (EBV) mimics a constitutively active B-cell receptor (BCR) and plays a key role in viral latency and EBV pathogenesis. By functioning as a BCR mimic, LMP-2A drives B-cell development, resulting in the bypass of normal B-cell developmental checkpoints. To assess the function of LMP-2A, we have utilized a colony formation assay for the progenitor B cells that uses the B-cell proliferation factor IL-7.Entities:
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Year: 2005 PMID： 15507715 DOI： 10.1385/1-59259-848-x:279
Source DB: PubMed Journal: Methods Mol Biol ISSN： 1064-3745