Literature DB >> 15507289

Phenotyping the haemostatic system by thrombography--potential for the estimation of thrombotic risk.

Véronique Regnault1, H Coenraad Hemker, Denis Wahl, Thomas Lecompte.   

Abstract

The aim of this paper is to review the thrombogram and its use for phenotyping the haemostatic system. The thrombogram can be readily obtained through Calibrated Automated Thrombography (CAT), using a commercially available fluorometer, dedicated software (Thrombinoscope) and a calibrator. Here we explore the possibility to use platelet-rich plasma (PRP) triggered with a low amount of recombinant human tissue factor (approximately 0.5 pM) and also explore the function of the protein C system by adding activated protein C (APC) or soluble recombinant thrombomodulin (TM). Examples are shown: inherited antithrombin (AT) and protein C deficiencies, and antiphospholipid antibodies.

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Year:  2004        PMID： 15507289     DOI： 10.1016/j.thromres.2004.06.017

Source DB:  PubMed          Journal:  Thromb Res        ISSN： 0049-3848            Impact factor:   3.944


  13 in total

1.  Quantification of hypercoagulable state after blunt trauma: microparticle and thrombin generation are increased relative to injury severity, while standard markers are not.

Authors:  Myung S Park; Barbara A L Owen; Beth A Ballinger; Michael G Sarr; Henry J Schiller; Scott P Zietlow; Donald H Jenkins; Mark H Ereth; Whyte G Owen; John A Heit
Journal:  Surgery       Date:  2012-02-07       Impact factor: 3.982

2.  Functional changes in hemostasis during asexual and sexual parasitemia in a controlled human malaria infection.

Authors:  Shengshi Huang; Wouter van der Heijden; Isaie J Reuling; Jun Wan; Qiuting Yan; Romy M W de Laat-Kremers; Andre J Van der Ven; Philip G de Groot; Matthew McCall; Robert W Sauerwein; Teun Bousema; Mark Roest; Marisa Ninivaggi; Quirijn de Mast; Bas de Laat
Journal:  PLoS One       Date:  2022-07-15       Impact factor: 3.752

3.  Increased BMI and Blood Lipids Are Associated With a Hypercoagulable State in the Moli-sani Cohort.

Authors:  Romy de Laat-Kremers; Augusto Di Castelnuovo; Lisa van der Vorm; Simona Costanzo; Marisa Ninivaggi; Chiara Cerletti; Dana Huskens; Amalia De Curtis; Alessandro Gialluisi; Cuicui Bai; Giovanni de Gaetano; Dongmei Yin; Maria Benedetta Donati; Bas de Laat; Licia Iacoviello
Journal:  Front Cardiovasc Med       Date:  2022-06-16

Review 4.  Mechanisms of antiphospholipid-induced thrombosis: effects on the protein C system.

Authors:  Denis Wahl; Aurélie Membre; Christine Perret-Guillaume; Véronique Regnault; Thomas Lecompte
Journal:  Curr Rheumatol Rep       Date:  2009-02       Impact factor: 4.592

Review 5.  Modeling thrombin generation: plasma composition based approach.

Authors:  Kathleen E Brummel-Ziedins; Stephen J Everse; Kenneth G Mann; Thomas Orfeo
Journal:  J Thromb Thrombolysis       Date:  2014-01       Impact factor: 2.300

6.  Effects of tissue factor, thrombomodulin and elevated clotting factor levels on thrombin generation in the calibrated automated thrombogram.

Authors:  Kellie R Machlus; Emily A Colby; Jogin R Wu; Gary G Koch; Nigel S Key; Alisa S Wolberg
Journal:  Thromb Haemost       Date:  2009-11       Impact factor: 5.249

Review 7.  Empirical and theoretical phenotypic discrimination.

Authors:  K E Brummel-Ziedins; T Orfeo; F R Rosendaal; A Undas; G E Rivard; S Butenas; K G Mann
Journal:  J Thromb Haemost       Date:  2009-07       Impact factor: 5.824

8.  Defining the boundaries of normal thrombin generation: investigations into hemostasis.

Authors:  Christopher M Danforth; Thomas Orfeo; Stephen J Everse; Kenneth G Mann; Kathleen E Brummel-Ziedins
Journal:  PLoS One       Date:  2012-02-02       Impact factor: 3.240

9.  Thrombin Generation Kinetics are Predictive of Rapid Transfusion in Trauma Patients Meeting Critical Administration Threshold.

Authors:  Taleen A MacArthur; Grant M Spears; Rosemary A Kozar; Jing-Fei Dong; Matthew Auton; Donald H Jenkins; Kent R Bailey; Aneel A Ashrani; Mike J Ferrara; Joseph M Immermann; Timothy M Halling; Myung S Park
Journal:  Shock       Date:  2021-03-01       Impact factor: 3.533

10.  Implication of Free Fatty Acids in Thrombin Generation and Fibrinolysis in Vascular Inflammation in Zucker Rats and Evolution with Aging.

Authors:  Jérémy Lagrange; Mélusine Didelot; Amel Mohamadi; Lucy A Walton; Saartje Bloemen; Bas de Laat; Huguette Louis; Simon N Thornton; Brian Derby; Michael J Sherratt; Bruno Fève; Pascal Challande; Riaz Akhtar; J Kennedy Cruickshank; Patrick Lacolley; Véronique Regnault
Journal:  Front Physiol       Date:  2017-11-22       Impact factor: 4.566
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