| Literature DB >> 15507204 |
Abstract
A central question in cancer biology is whether malignancy arises in self-renewing tissue stem cells that suffer oncogene activation or in differentiated cells that acquire properties of unremitting self-renewal? In two papers, Weissman and colleagues document both mechanisms: chronic leukemia arising by mutation affecting the hematopoietic stem cell (HSC) and acute leukemia evolving from committed granulocyte-macrophage progenitors that have acquired the self-renewal machinery of HSCs.Entities:
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Year: 2004 PMID： 15507204 DOI： 10.1016/j.cell.2004.10.015
Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582