S Bruce Greenberg1, Sadaf T Bhutta, Robert F Buchmann. 1. Arkansas Children's Hospital, University of Arkansas for Medical Sciences, 800 Marshall Street, Little Rock, AR 72202, USA. greenbergsbruce@uams.edu
Abstract
BACKGROUND: Gadolinium-enhanced magnetic resonance angiography (MRA)is a well-established technique in older children and adults. No studies have focused on its use in neonates and small infants. OBJECTIVE: Our objective was to study the use of gadolinium-enhanced MRA in neonates and infants suspected of caval or aortic thrombosis. MATERIALS AND METHODS: Gadolinium-enhanced MR angiography was performed on seven neonates and small infants for the evaluation of caval or aortic thrombosis. Gadolinium-DTPA at a dose of 0.3 mmol/kg (minimum dose 1 ml) was injected using a power injector (0.2 ml/s). Contrast-enhanced MRA was performed using a 3-D, fast, radiofrequency spoiled gradient-echo sequence (TR/TE: 4.8/1.1, flip angle 45 degrees , matrix 256 x 128, slice thickness 2.6 mm interpolated to 1.3 mm, FOV variable, NEX=1.0). RESULTS: Diagnostic-quality angiograms were obtained in all seven neonates. Superior vena cava thrombosis was identified in two neonates, and abdominal aortic thrombosis was present in one neonate. CONCLUSION: It is practical to perform gadolinium-enhanced MRA in neonates weighing as little as 600 g for the detection of caval or aortic thrombosis.
BACKGROUND:Gadolinium-enhanced magnetic resonance angiography (MRA)is a well-established technique in older children and adults. No studies have focused on its use in neonates and small infants. OBJECTIVE: Our objective was to study the use of gadolinium-enhanced MRA in neonates and infants suspected of caval or aortic thrombosis. MATERIALS AND METHODS:Gadolinium-enhanced MR angiography was performed on seven neonates and small infants for the evaluation of caval or aortic thrombosis. Gadolinium-DTPA at a dose of 0.3 mmol/kg (minimum dose 1 ml) was injected using a power injector (0.2 ml/s). Contrast-enhanced MRA was performed using a 3-D, fast, radiofrequency spoiled gradient-echo sequence (TR/TE: 4.8/1.1, flip angle 45 degrees , matrix 256 x 128, slice thickness 2.6 mm interpolated to 1.3 mm, FOV variable, NEX=1.0). RESULTS: Diagnostic-quality angiograms were obtained in all seven neonates. Superior vena cava thrombosis was identified in two neonates, and abdominal aortic thrombosis was present in one neonate. CONCLUSION: It is practical to perform gadolinium-enhanced MRA in neonates weighing as little as 600 g for the detection of caval or aortic thrombosis.
Authors: S A Thurnher; A Capelastegui; F H Del Olmo; R F Dondelinger; C Gervás; A G Jassoy; P Keto; C Loewe; C N Ludman; L Marti-Bonmati; M Meusel; J P da Cruz; J P Pruvo; V M Sanjuan; T Vogl Journal: Radiology Date: 2001-04 Impact factor: 11.105
Authors: T Masui; M Katayama; S Kobayashi; T Ito; M Seguchi; M Koide; A Nozaki; H Sakahara Journal: J Magn Reson Imaging Date: 2000-12 Impact factor: 4.813
Authors: J K Tam; W G Bradley; S K Goergen; D Y Chen; P J Pema; M D Dubin; L M Teresi; J E Jordan Journal: Radiology Date: 1996-01 Impact factor: 11.105
Authors: M Filippi; M Rovaris; R Capra; C Gasperini; T A Yousry; M P Sormani; F Prandini; M A Horsfield; V Martinelli; S Bastianello; I Kühne; C Pozzilli; G Comi Journal: Brain Date: 1998-10 Impact factor: 13.501
Authors: J Haustein; M Laniado; H P Niendorf; T Louton; W Beck; J Planitzer; M Schöffel; M Reiser; W Kaiser; W Schörner Journal: Radiology Date: 1993-03 Impact factor: 11.105