Literature DB >> 15501811

Comparative analysis of locus of enterocyte effacement pathogenicity islands of atypical enteropathogenic Escherichia coli.

Julia F Gärtner1, M Alexander Schmidt.   

Abstract

The pathogenicity of enteropathogenic Escherichia coli (EPEC) is linked to the locus of enterocyte effacement, or LEE, encoding a type III secretion system (T3SS) that directly transfers bacterial effector proteins into eukaryotic cells. Atypical diffusely adhering EPEC (DA-EPEC) strains that harbor homologues of the LEE but lack the EPEC adherence factor plasmid have been increasingly associated with outbreaks of diarrhea. In this study, we have completely sequenced and functionally characterized LEE pathogenicity islands derived from the clinical DA-EPEC isolates 3431 (O8:H-) and 0181 (O119:H9:K61). LEE3431 and LEE0181 exhibit genetic organization analogous to that of the prototype LEE(E2348/69). Genes constituting the T3SS apparatus are highly conserved. However, LEE-encoded effector proteins exhibit major differences. Transfer and functional expression of LEE0181 in an E. coli XL1 blue MR background demonstrated that LEE0181 contains all the information for signal transduction and pedestal formation.

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Year:  2004        PMID： 15501811      PMCID： PMC523029          DOI： 10.1128/IAI.72.11.6722-6728.2004

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  31 in total

1.  Translocated EspF protein from enteropathogenic Escherichia coli disrupts host intestinal barrier function.

Authors:  B P McNamara; A Koutsouris; C B O'Connell; J P Nougayréde; M S Donnenberg; G Hecht
Journal:  J Clin Invest       Date:  2001-03       Impact factor: 14.808

2.  Expression of the EspB protein of enteropathogenic Escherichia coli within HeLa cells affects stress fibers and cellular morphology.

Authors:  K A Taylor; P W Luther; M S Donnenberg
Journal:  Infect Immun       Date:  1999-01       Impact factor: 3.441

3.  Virulence-related DNA sequences and adherence patterns in strains of enteropathogenic Escherichia coli.

Authors:  S Bouzari; M N Jafari; F Shokouhi; M Parsi; A Jafari
Journal:  FEMS Microbiol Lett       Date:  2000-04-01       Impact factor: 2.742

4.  Identification and characterization of a novel genomic island integrated at selC in locus of enterocyte effacement-negative, Shiga toxin-producing Escherichia coli.

Authors:  H Schmidt; W L Zhang; U Hemmrich; S Jelacic; W Brunder; P I Tarr; U Dobrindt; J Hacker; H Karch
Journal:  Infect Immun       Date:  2001-11       Impact factor: 3.441

5.  Complete nucleotide sequence and analysis of the locus of enterocyte Effacement from rabbit diarrheagenic Escherichia coli RDEC-1.

Authors:  C Zhu; T S Agin; S J Elliott; L A Johnson; T E Thate; J B Kaper; E C Boedeker
Journal:  Infect Immun       Date:  2001-04       Impact factor: 3.441

6.  Characterization of enteropathogenic and enteroaggregative Escherichia coli isolated from diarrheal outbreaks.

Authors:  Jun Yatsuyanagi; Shioko Saito; Hiroyasu Sato; Yoshimichi Miyajima; Ken-Ichi Amano; Katsuhiko Enomoto
Journal:  J Clin Microbiol       Date:  2002-01       Impact factor: 5.948

7.  The locus of enterocyte effacement (LEE)-encoded regulator controls expression of both LEE- and non-LEE-encoded virulence factors in enteropathogenic and enterohemorrhagic Escherichia coli.

Authors:  S J Elliott; V Sperandio; J A Girón; S Shin; J L Mellies; L Wainwright; S W Hutcheson; T K McDaniel; J B Kaper
Journal:  Infect Immun       Date:  2000-11       Impact factor: 3.441

8.  Enteropathogenic Escherichia coli translocated intimin receptor, Tir, requires a specific chaperone for stable secretion.

Authors:  A Abe; M de Grado; R A Pfuetzner; C Sánchez-Sanmartín; R Devinney; J L Puente; N C Strynadka; B B Finlay
Journal:  Mol Microbiol       Date:  1999-09       Impact factor: 3.501

9.  Virulence properties of atypical EPEC strains.

Authors:  J S Pelayo; I C A Scaletsky; M Z Pedroso; V Sperandio; J A Girón; G Frankel; L R Trabulsi
Journal:  J Med Microbiol       Date:  1999-01       Impact factor: 2.472

10.  Detection of intimins alpha, beta, gamma, and delta, four intimin derivatives expressed by attaching and effacing microbial pathogens.

Authors:  J Adu-Bobie; G Frankel; C Bain; A G Goncalves; L R Trabulsi; G Douce; S Knutton; G Dougan
Journal:  J Clin Microbiol       Date:  1998-03       Impact factor: 5.948
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  14 in total

Review 1.  Genome dynamics and its impact on evolution of Escherichia coli.

Authors:  Ulrich Dobrindt; M Geddam Chowdary; G Krumbholz; J Hacker
Journal:  Med Microbiol Immunol       Date:  2010-05-06       Impact factor: 3.402

2.  Atypical enteropathogenic Escherichia coli that contains functional locus of enterocyte effacement genes can be attaching-and-effacing negative in cultured epithelial cells.

Authors:  Sérgio P D Rocha; Cecilia M Abe; Vanessa Sperandio; Silvia Y Bando; Waldir P Elias
Journal:  Infect Immun       Date:  2011-02-22       Impact factor: 3.441

3.  Rapid identification and differentiation of clinical isolates of enteropathogenic Escherichia coli (EPEC), atypical EPEC, and Shiga toxin-producing Escherichia coli by a one-step multiplex PCR method.

Authors:  Daniel Müller; Peter Hagedorn; Sabine Brast; Gerhard Heusipp; Martina Bielaszewska; Alexander W Friedrich; Helge Karch; M Alexander Schmidt
Journal:  J Clin Microbiol       Date:  2006-07       Impact factor: 5.948

4.  Use of the espZ gene encoded in the locus of enterocyte effacement for molecular typing of shiga toxin-producing Escherichia coli.

Authors:  Matthew W Gilmour; Dobryan M Tracz; Ashleigh K Andrysiak; Clifford G Clark; Shari Tyson; Alberto Severini; Lai-King Ng
Journal:  J Clin Microbiol       Date:  2006-02       Impact factor: 5.948

5.  Identification of two translocon proteins of Vibrio parahaemolyticus type III secretion system 2.

Authors:  Toshio Kodama; Hirotaka Hiyoshi; Kazuyoshi Gotoh; Yukihiro Akeda; Shigeaki Matsuda; Kwon-Sam Park; Vlademir V Cantarelli; Tetsuya Iida; Takeshi Honda
Journal:  Infect Immun       Date:  2008-06-09       Impact factor: 3.441

6.  Comparative analysis of the locus of enterocyte effacement and its flanking regions.

Authors:  Daniel Müller; Inga Benz; Ariane Liebchen; Inka Gallitz; Helge Karch; M Alexander Schmidt
Journal:  Infect Immun       Date:  2009-06-08       Impact factor: 3.441

7.  Estimating the prevalence of potential enteropathogenic Escherichia coli and intimin gene diversity in a human community by monitoring sanitary sewage.

Authors:  Kun Yang; Eulyn Pagaling; Tao Yan
Journal:  Appl Environ Microbiol       Date:  2013-10-18       Impact factor: 4.792

8.  Systematic identification and sequence analysis of the genomic islands of the enteropathogenic Escherichia coli strain B171-8 by the combined use of whole-genome PCR scanning and fosmid mapping.

Authors:  Yoshitoshi Ogura; Hiroyuki Abe; Keisuke Katsura; Ken Kurokawa; Md Asadulghani; Atsushi Iguchi; Tadasuke Ooka; Keisuke Nakayama; Atsushi Yamashita; Masahira Hattori; Toru Tobe; Tetsuya Hayashi
Journal:  J Bacteriol       Date:  2008-08-29       Impact factor: 3.490

9.  Phenotypic and Genotypic Characterization of Enteropathogenic Escherichia coli (EPEC) strains in Tehran, Iran.

Authors:  Mr Asadi Karam; S Bouzari; M Oloomi; Mm Aslani; A Jafari
Journal:  Iran J Microbiol       Date:  2010-03

10.  Evolution of atypical enteropathogenic E. coli by repeated acquisition of LEE pathogenicity island variants.

Authors:  Danielle J Ingle; Marija Tauschek; David J Edwards; Dianna M Hocking; Derek J Pickard; Kristy I Azzopardi; Thakshila Amarasena; Vicki Bennett-Wood; Jaclyn S Pearson; Boubou Tamboura; Martin Antonio; John B Ochieng; Joseph Oundo; Inácio Mandomando; Shahida Qureshi; Thandavarayan Ramamurthy; Anowar Hossain; Karen L Kotloff; James P Nataro; Gordon Dougan; Myron M Levine; Roy M Robins-Browne; Kathryn E Holt
Journal:  Nat Microbiol       Date:  2016-01-18       Impact factor: 17.745
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