| Literature DB >> 15501054 |
Yoshiki Kashiwada1, Michiko Sekiya, Yasumasa Ikeshiro, Toshihiro Fujioka, Nicole R Kilgore, Carl T Wild, Graham P Allaway, Kuo-Hsiung Lee.
Abstract
3-O-Acyl-betulin and -dihydrobetulin derivatives were prepared and evaluated for anti-HIV activity. 3-O-Glutaryl-dihydrobetulin (17) demonstrated extremely potent anti-HIV activity with an EC(50) value of 2 x 10(-5) microM and a TI value of 1.12 x 10(6). 3-O-(3',3'-Dimethylsuccinyl)- and 3-O-(3',3'-dimethylglutaryl)-dihydrobetulins (15, 16) were also potent anti-HIV compounds with EC(50) values of 0.0017 and 0.0013 microM, respectively, and TI values of 16,160 and 19,530, respectively.Entities:
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Year: 2004 PMID： 15501054 DOI： 10.1016/j.bmcl.2004.09.033
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823