Literature DB >> 15498575

Sizing the pore of the volume-sensitive anion channel by differential polymer partitioning.

Vadim I Ternovsky1, Yasunobu Okada, Ravshan Z Sabirov.   

Abstract

Partitioning of ethylene glycol and its polymeric forms into the pore of the volume-sensitive outwardly rectifying (VSOR) anion channel was studied to assess the pore size. Polyethylene glycol (PEG) PEG 200-300 (Rh = 0.27-0.53 nm) effectively suppressed the single-channel currents, whereas PEG 400-4000 (Rh = 0.62-1.91 nm) had little or no effect. Since all the molecules tested effectively decreased electric conductivity of the bulk solution, the observed differential effects between PEG 200-300 and PEG 400-4000 on the VSOR single-channel current are due to their limited partitioning into the channel lumen. The cut-off radius of the VSOR channel pore was assessed to be 0.63 nm.

Entities:  

Mesh：

Substances：

Year:  2004        PMID： 15498575     DOI： 10.1016/j.febslet.2004.09.051

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  32 in total

Review 1.  Volume-regulated anion channel--a frenemy within the brain.

Authors:  Alexander A Mongin
Journal:  Pflugers Arch       Date:  2015-12-01       Impact factor: 3.657

2.  Pseudomonas aeruginosa porin OprF: properties of the channel.

Authors:  Ekaterina M Nestorovich; Etsuko Sugawara; Hiroshi Nikaido; Sergey M Bezrukov
Journal:  J Biol Chem       Date:  2006-04-14       Impact factor: 5.157

3.  Surface accessibility and conformational changes in the N-terminal domain of type I inositol trisphosphate receptors: studies using cysteine substitution mutagenesis.

Authors:  Georgia Anyatonwu; Suresh K Joseph
Journal:  J Biol Chem       Date:  2009-01-13       Impact factor: 5.157

Review 4.  GABA(A) receptor and glycine receptor activation by paracrine/autocrine release of endogenous agonists: more than a simple communication pathway.

Authors:  Herve Le-Corronc; Jean-Michel Rigo; Pascal Branchereau; Pascal Legendre
Journal:  Mol Neurobiol       Date:  2011-05-06       Impact factor: 5.590

Review 5.  Obstructing toxin pathways by targeted pore blockage.

Authors:  Ekaterina M Nestorovich; Sergey M Bezrukov
Journal:  Chem Rev       Date:  2012-10-11       Impact factor: 60.622

6.  Membrane-dependent oligomeric structure and pore formation of a beta-hairpin antimicrobial peptide in lipid bilayers from solid-state NMR.

Authors:  Rajeswari Mani; Sarah D Cady; Ming Tang; Alan J Waring; Robert I Lehrer; Mei Hong
Journal:  Proc Natl Acad Sci U S A       Date:  2006-10-23       Impact factor: 11.205

7.  Pore forming activity of the potent RTX-toxin produced by pediatric pathogen Kingella kingae: Characterization and comparison to other RTX-family members.

Authors:  Iván Bárcena-Uribarri; Roland Benz; Mathias Winterhalter; Eleonora Zakharian; Nataliya Balashova
Journal:  Biochim Biophys Acta       Date:  2015-04-07

8.  Molecular dynamics studies of polyethylene oxide and polyethylene glycol: hydrodynamic radius and shape anisotropy.

Authors:  Hwankyu Lee; Richard M Venable; Alexander D Mackerell; Richard W Pastor
Journal:  Biophys J       Date:  2008-05-02       Impact factor: 4.033

9.  Distinct pharmacological and molecular properties of the acid-sensitive outwardly rectifying (ASOR) anion channel from those of the volume-sensitive outwardly rectifying (VSOR) anion channel.

Authors:  Kaori Sato-Numata; Tomohiro Numata; Ryuji Inoue; Yasunobu Okada
Journal:  Pflugers Arch       Date:  2016-01-08       Impact factor: 3.657

Review 10.  Biophysics and Physiology of the Volume-Regulated Anion Channel (VRAC)/Volume-Sensitive Outwardly Rectifying Anion Channel (VSOR).

Authors:  Stine F Pedersen; Yasunobu Okada; Bernd Nilius
Journal:  Pflugers Arch       Date:  2016-01-06       Impact factor: 3.657
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.