BACKGROUND: Pulmonary hypertension, a characteristic of chronic obstructive pulmonary disease (COPD) has led us to investigate polymorphisms in angiotensin-converting enzyme (ACE) and endothelial nitric oxide synthase (eNOS) genes. DESIGN AND METHODS: Sixty-six normal and 27 patients, all of whom were smokers, were screened for ACE Insertion/Deletion (I/D) and eNOS G894T and CA-repeat polymorphisms and for plasma ACE and NO levels. RESULTS: Elevated ACE and decreased NO levels were obtained with the pattern of II to ID to DD and GG to GT to TT conversion, respectively. Furthermore, the genotype combination of II and GG was significantly greater in controls as compared to patients (P = 0.01; OR = 2.43; 95% CI: 1.21-4.87; RR = 2.00, 1.15-3.48). The CA-repeat multialleles showed a trimodal pattern in both the groups with a frequency range of 0.0057-0.103 and 0.0208-0.1875 in the controls and patients, respectively. CONCLUSIONS: The lower ACE and higher NO levels by virtue of the interchromosomal interaction between the I and G alleles appear to cause less vasoconstriction and increase vasodilatation that may be advantageous in the improvement of the disease.
BACKGROUND:Pulmonary hypertension, a characteristic of chronic obstructive pulmonary disease (COPD) has led us to investigate polymorphisms in angiotensin-converting enzyme (ACE) and endothelial nitric oxide synthase (eNOS) genes. DESIGN AND METHODS: Sixty-six normal and 27 patients, all of whom were smokers, were screened for ACE Insertion/Deletion (I/D) and eNOSG894T and CA-repeat polymorphisms and for plasma ACE and NO levels. RESULTS: Elevated ACE and decreased NO levels were obtained with the pattern of II to ID to DD and GG to GT to TT conversion, respectively. Furthermore, the genotype combination of II and GG was significantly greater in controls as compared to patients (P = 0.01; OR = 2.43; 95% CI: 1.21-4.87; RR = 2.00, 1.15-3.48). The CA-repeat multialleles showed a trimodal pattern in both the groups with a frequency range of 0.0057-0.103 and 0.0208-0.1875 in the controls and patients, respectively. CONCLUSIONS: The lower ACE and higher NO levels by virtue of the interchromosomal interaction between the I and G alleles appear to cause less vasoconstriction and increase vasodilatation that may be advantageous in the improvement of the disease.
Authors: Janet G Shaw; Annette G Dent; Linda H Passmore; Darryl J Burstow; Rayleen V Bowman; Paul V Zimmerman; Kwun M Fong; Ian A Yang Journal: BMC Pulm Med Date: 2012-06-13 Impact factor: 3.317
Authors: Sang Wook Kang; Su Kang Kim; Joo-Ho Chung; Hee-Jae Jung; Kwan-Il Kim; Jinju Kim; Ju Yeon Ban Journal: Biomed Res Int Date: 2016-10-18 Impact factor: 3.411
Authors: Nur Ilyana Jaafar; Ramachandran Vasudevan; Patimah Ismail; Ahmad Fazli Abdul Aziz; Nur Afiqah Mohamad; Geetha Kandavello; Raja Nurzatul Effah Raja Adnan; Vinod Balasubramaniam Journal: J Cardiovasc Dev Dis Date: 2018-09-18
Authors: Farzian Aminuddin; Tillie-Louise Hackett; Dorota Stefanowicz; Aabida Saferali; Peter D Paré; Amund Gulsvik; Per Bakke; Michael H Cho; Augusto Litonjua; David A Lomas; Wayne H Anderson; Terri H Beaty; Edwin K Silverman; Andrew J Sandford Journal: BMC Pulm Med Date: 2013-11-06 Impact factor: 3.317