Literature DB >> 15497951

A novel antimicrobial indolizinium alkaloid from Aniba panurensis.

Paul Klausmeyer1, Gwendolyn N Chmurny, Thomas G McCloud, Kenneth D Tucker, Robert H Shoemaker.   

Abstract

Activity-guided fractionation of an Aniba panurensis organic solvent extract has led to the isolation of the novel alkaloid 6,8-didec-(1Z)-enyl-5,7-dimethyl-2,3-dihydro-1H-indolizinium, as the trifluoroacetic acid salt (1). Its structure was determined by NMR and mass spectrometry. Bioassays performed in vitro demonstrated toxicity of compound 1 to a drug-resistant strain of Candida albicans.

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Year:  2004        PMID： 15497951     DOI： 10.1021/np040114e

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  7 in total

1.  Anibamine, a natural product CCR5 antagonist, as a novel lead for the development of anti-prostate cancer agents.

Authors:  Xueping Zhang; Kendra M Haney; Amanda C Richardson; Eden Wilson; David A Gewirtz; Joy L Ware; Zendra E Zehner; Yan Zhang
Journal:  Bioorg Med Chem Lett       Date:  2010-06-08       Impact factor: 2.823

2.  Anibamine and Its Analogues: Potent Antiplasmodial Agents from Aniba citrifolia.

Authors:  Yongle Du; Ana Lisa Valenciano; Yumin Dai; Yi Zheng; Feng Zhang; Yan Zhang; Jason Clement; Michael Goetz; David G I Kingston; Maria B Cassera
Journal:  J Nat Prod       Date:  2019-10-02       Impact factor: 4.050

3.  Regio- and stereoselective syntheses of the natural product CCR5 antagonist anibamine and its three olefin isomers.

Authors:  Feng Zhang; Saheem Zaidi; Kendra M Haney; Glen E Kellogg; Yan Zhang
Journal:  J Org Chem       Date:  2011-09-13       Impact factor: 4.354

4.  Discovery and preliminary SAR of bisbenzylisoquinoline alkaloids as inducers of C/EBPα.

Authors:  Paul Klausmeyer; Thomas G McCloud; Dominic A Scudiero; Michael J Currens; John H Cardellina Ii; Robert H Shoemaker
Journal:  Bioorg Med Chem       Date:  2012-06-16       Impact factor: 3.641

5.  The Antibacterial Activity of Cassia fistula Organic Extracts.

Authors:  Seyyed Mansour Seyyednejad; Hossein Motamedi; Mouzhan Vafei; Ameneh Bakhtiari
Journal:  Jundishapur J Microbiol       Date:  2014-01-01       Impact factor: 0.747

6.  High throughput extraction of plant, marine and fungal specimens for preservation of biologically active molecules.

Authors:  Thomas G McCloud
Journal:  Molecules       Date:  2010-06-24       Impact factor: 4.411

Review 7.  Review on Plant-Based Management in Combating Antimicrobial Resistance - Mechanistic Perspective.

Authors:  Masita Arip; Malarvili Selvaraja; Mogana R; Lee Fang Tan; Mun Yee Leong; Puay Luan Tan; Vi Lien Yap; Sasikala Chinnapan; Ng Chin Tat; Maha Abdullah; Dharmendra K; Najwan Jubair
Journal:  Front Pharmacol       Date:  2022-09-29       Impact factor: 5.988
  7 in total

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