Literature DB >> 15491776

Not all progestins are the same: implications for usage.

Janet P Hapgood1, Dominique Koubovec, Ann Louw, Donita Africander.   

Abstract

Recent clinical evidence showing unexpected side-effects of progestins used in contraception and hormone replacement therapy has highlighted the importance of choice of synthetic progestin. The molecular mechanisms of action of the relatively nonspecific and most widely used synthetic progestins, medroxyprogesterone acetate and norethisterone, are discussed in the context of this recent clinical evidence. Future directions involving a more mechanism-based approach for improved therapeutics, with greater specificity and fewer side-effects, are discussed.

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Year:  2004        PMID： 15491776     DOI： 10.1016/j.tips.2004.09.005

Source DB:  PubMed          Journal:  Trends Pharmacol Sci        ISSN： 0165-6147            Impact factor:   14.819


  19 in total

1.  Comparing the androgenic and estrogenic properties of progestins used in contraception and hormone therapy.

Authors:  Renate Louw-du Toit; Meghan S Perkins; Janet P Hapgood; Donita Africander
Journal:  Biochem Biophys Res Commun       Date:  2017-07-12       Impact factor: 3.575

Review 2.  Hormonal Contraception and HIV-1 Acquisition: Biological Mechanisms.

Authors:  Janet P Hapgood; Charu Kaushic; Zdenek Hel
Journal:  Endocr Rev       Date:  2018-02-01       Impact factor: 19.871

3.  Hormonal contraceptive use before and after conception in relation to preterm birth and small for gestational age: an observational cohort study.

Authors:  E T Jensen; J L Daniels; T Stürmer; W R Robinson; C J Williams; K Vejrup; P Magnus; M P Longnecker
Journal:  BJOG       Date:  2014-10-16       Impact factor: 6.531

4.  Quantitative histomorphometric analysis of gonadal steroid receptor distribution in the normal human endometrium through the menstrual cycle.

Authors:  Anthony H Taylor; Muna Guzail; May Wahab; John R Thompson; Farook Al-Azzawi
Journal:  Histochem Cell Biol       Date:  2005-05-12       Impact factor: 4.304

5.  Synthetic gestagens exert differential effects on arterial thrombosis and aortic gene expression in ovariectomized apolipoprotein E-deficient mice.

Authors:  T Freudenberger; R Deenen; I Kretschmer; A Zimmermann; L F Seiler; P Mayer; H-K Heim; K Köhrer; J W Fischer
Journal:  Br J Pharmacol       Date:  2014-09-05       Impact factor: 8.739

6.  Microbial Composition Predicts Genital Tract Inflammation and Persistent Bacterial Vaginosis in South African Adolescent Females.

Authors:  Katie Lennard; Smritee Dabee; Shaun L Barnabas; Enock Havyarimana; Anna Blakney; Shameem Z Jaumdally; Gerrit Botha; Nonhlanhla N Mkhize; Linda-Gail Bekker; David A Lewis; Glenda Gray; Nicola Mulder; Jo-Ann S Passmore; Heather B Jaspan
Journal:  Infect Immun       Date:  2017-12-19       Impact factor: 3.441

7.  Progesterone and Nestorone facilitate axon remyelination: a role for progesterone receptors.

Authors:  Rashad Hussain; Martine El-Etr; Ouardia Gaci; Jennifer Rakotomamonjy; Wendy B Macklin; Narender Kumar; Regine Sitruk-Ware; Michael Schumacher; Abdel M Ghoumari
Journal:  Endocrinology       Date:  2011-08-09       Impact factor: 4.736

8.  Differential metabolism of clinically-relevant progestogens in cell lines and tissue: Implications for biological mechanisms.

Authors:  Salndave B Skosana; John G Woodland; Meghan Cartwright; Kim Enfield; Maleshigo Komane; Renate Louw-du Toit; Zephne van der Spuy; Chanel Avenant; Donita Africander; Karl-Heinz Storbeck; Janet P Hapgood
Journal:  J Steroid Biochem Mol Biol       Date:  2019-02-26       Impact factor: 4.292

9.  Medroxyprogesterone acetate differentially regulates interleukin (IL)-12 and IL-10 in a human ectocervical epithelial cell line in a glucocorticoid receptor (GR)-dependent manner.

Authors:  Renate Louw-du Toit; Janet P Hapgood; Donita Africander
Journal:  J Biol Chem       Date:  2014-09-08       Impact factor: 5.157

10.  Involvement of cyclin B1 in progesterone-mediated cell growth inhibition, G2/M cell cycle arrest, and apoptosis in human endometrial cell.

Authors:  Li Tang; Yu Zhang; Hong Pan; Qiong Luo; Xiao-Ming Zhu; Min-Yue Dong; Peter Ck Leung; Jian-Zhong Sheng; He-Feng Huang
Journal:  Reprod Biol Endocrinol       Date:  2009-12-07       Impact factor: 5.211
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