Literature DB >> 15490334

Xanthones from Gentiana campestris as new acetylcholinesterase inhibitors.

Aurélie Urbain1, Andrew Marston, Emerson Ferreira Queiroz, Karine Ndjoko, Kurt Hostettmann.   

Abstract

In order to discover new acetylcholinesterase (AChE) inhibitors, different plant extracts were screened by a previously established TLC bioautographic method. The methanol extract of Gentiana campestris leaves exhibited significant inhibition of AChE activity. A bioactivity-guided fractionation approach was undertaken to isolate the active components. Four xanthones, bellidin, bellidifolin, bellidin 8-O-beta-glucopyranoside (norswertianolin), and bellidifolin 8-O-beta-glucopyranoside (swertianolin), were found to be responsible for the anti-AChE activity effects. Bellidifolin showed similar activity to galanthamine in this enzyme assay.

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Year:  2004        PMID： 15490334     DOI： 10.1055/s-2004-832632

Source DB:  PubMed          Journal:  Planta Med        ISSN： 0032-0943            Impact factor:   3.352


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