| Literature DB >> 15482919 |
Bradley Newhouse1, Shelley Allen, Benjamin Fauber, Aaron S Anderson, C Todd Eary, Joshua D Hansen, Justin Schiro, John J Gaudino, Ellen Laird, David Chantry, Christine Eberhardt, Laurence E Burgess.
Abstract
A series of racemic and chiral, nonracemic lactams that display high binding affinities, functional chemotaxis antagonism, and selectivity toward CCR4 are described. Compound 41, which provides reasonably high blood levels in mice when dosed intraperitoneally, was identified as a useful pharmacological tool to explore the role of CCR4 antagonism in animal models of allergic disease.Entities:
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Year: 2004 PMID： 15482919 DOI： 10.1016/j.bmcl.2004.09.001
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823