Literature DB >> 1548280

The additive effect of alpha-difluoromethylornithine (DFMO) and radiation therapy on a rat glioma model.

T Tsukahara1, M Tamura, H Yamazaki, H Kurihara, S Matsuzaki.   

Abstract

The effects of alpha-difluoromethylornithine (DFMO), radiation and the therapy of their combination were investigated in rats bearing G-XII glioma. DFMO treatment as well as radiation therapy prolonged the survival period when compared to the results in non-treated control rats. The combination therapy showed a greater effect on the survival rate than the single therapies, the effect being additive. The concentration of putrescine, spermidine, and N1-acetylspermidine in tumor tissue was lowered by DFMO, while that of spermine was slightly elevated. Radiation decreased the concentration of all the polyamines, putrescine, spermidine, spermine and N1-acetylspermidine. The concomitant treatment with DFMO and radiation further decreased the concentrations of putrescine and N1-acetylspermidine in tumor tissues. The survival period of glioma-bearing rats is inversely correlated with the tissue levels of putrescine plus N1-acetylspermidine.

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Year:  1992        PMID： 1548280     DOI： 10.1007/bf01410129

Source DB:  PubMed          Journal:  J Cancer Res Clin Oncol        ISSN： 0171-5216            Impact factor:   4.553


  21 in total

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Journal:  Arch Neurol       Date:  1977-09

2.  Depletion of intracellular polyamine content does not alter the survival of 9L rat brain tumour cells after X-irradiation.

Authors:  J Seidenfeld; D F Deen; L J Marton
Journal:  Int J Radiat Biol Relat Stud Phys Chem Med       Date:  1980-08

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Authors:  D F Deen; P J Tofilon
Journal:  Prog Exp Tumor Res       Date:  1984

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Authors:  S Matsuzaki; K Hamana; K Imai; K Matsuura
Journal:  Biochem Biophys Res Commun       Date:  1982-07-16       Impact factor: 3.575

5.  Polyamine metabolism in a rat brain tumor cell line: its relationship to the growth rate.

Authors:  O Heby; L J Marton; C B Wilson; H M Martinez
Journal:  J Cell Physiol       Date:  1975-12       Impact factor: 6.384

6.  Phase I-II study of eflornithine and mitoguazone combined in the treatment of recurrent primary brain tumors.

Authors:  V A Levin; M C Chamberlain; M D Prados; A K Choucair; M S Berger; P Silver; M Seager; P H Gutin; R L Davis; C B Wilson
Journal:  Cancer Treat Rep       Date:  1987-05

7.  Radiation therapy of rat brain tumor using misonidazole as hypoxic cell sensitizer.

Authors:  M Tamura; H Inoue; M Murata; H Koizumi; M Nakamura; I Yonome; H Niibe
Journal:  J Cancer Res Clin Oncol       Date:  1985       Impact factor: 4.553

8.  In situ cell kinetics studies on human neuroectodermal tumors with bromodeoxyuridine labeling.

Authors:  T Hoshino; T Nagashima; J A Murovic; C B Wilson; M S Edwards; P H Gutin; R L Davis; S J DeArmond
Journal:  J Neurosurg       Date:  1986-03       Impact factor: 5.115

9.  Elevated levels of free putrescine and N1-acetylspermidine in cyst fluids of malignant brain tumours.

Authors:  H Yamazaki; T Tsukahara; J Uki; S Matsuzaki
Journal:  J Neurol Neurosurg Psychiatry       Date:  1986-02       Impact factor: 10.154

10.  [Effect of hyperthermia in combination with radiation therapy in a rat glioma model].

Authors:  M Tamura; A Zama; H Kunimine; Y Tamaki; H Niibe
Journal:  No Shinkei Geka       Date:  1988
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  1 in total

1.  Combination treatment of TRAIL, DFMO and radiation for malignant glioma cells.

Authors:  George A Alexiou; Konstantinos I Tsamis; Evrysthenis Vartholomatos; Evangelia Peponi; Eftychia Tzima; Ifigeneia Tasiou; Efstathios Lykoudis; Pericles Tsekeris; Athanasios P Kyritsis
Journal:  J Neurooncol       Date:  2015-05-03       Impact factor: 4.130
  1 in total

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