Literature DB >> 1547974

Antifibrotic and uveitogenic properties of gamma interferon in the rabbit eye.

L M Hjelmeland1, J W Li, C A Toth, M B Landers.   

Abstract

The feasibility of gamma (gamma)-interferon injection for the treatment of ocular fibrotic conditions was studied in rabbits using recombinant rabbit gamma-interferon and the cell-injection model of tractional detachment. A toxicity study revealed that intravitreal injection of greater than 10(4) units gamma-interferon consistently produced panuveitis. For tractional detachment, 250,000 rabbit dermal fibroblasts were injected intravitreally into 20 eyes; 1 day later, 5 of these eyes received intravitreal injections of 10(4) units gamma-interferon, another 5 were given 10(6) units, and the remaining 10 received balanced salt solution. Slit-lamp examination and fundus photography were performed at regular intervals for 21 days and were graded by a masked observer. The eyes were then enucleated and processed for histology. Doses of 10(4) units gamma-interferon significantly reduced the severity of detachments, but injections of 10(6) units induced panuveitis.

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Year:  1992        PMID： 1547974     DOI： 10.1007/bf00166768

Source DB:  PubMed          Journal:  Graefes Arch Clin Exp Ophthalmol        ISSN： 0721-832X            Impact factor:   3.117


  17 in total

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Authors:  M Einat; D Resnitzky; A Kimchi
Journal:  Proc Natl Acad Sci U S A       Date:  1985-11       Impact factor: 11.205

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Authors:  Y Sokawa; Y Watanabe; Y Watanabe; Y Kawade
Journal:  Nature       Date:  1977-07-21       Impact factor: 49.962

3.  Therapy of chronic hepatitis B with recombinant human alpha and gamma interferon.

Authors:  A M Di Bisceglie; V K Rustgi; C Kassianides; M Lisker-Melman; Y Park; J G Waggoner; J H Hoofnagle
Journal:  Hepatology       Date:  1990-02       Impact factor: 17.425

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Authors:  M R Stratton; J M Martin; P L Lantos
Journal:  Br J Exp Pathol       Date:  1987-10

5.  Interferon inhibits the establishment of competence in Go/S-phase transition.

Authors:  S L Lin; T Kikuchi; W J Pledger; I Tamm
Journal:  Science       Date:  1986-07-18       Impact factor: 47.728

6.  Results of a multicenter placebo-controlled double-blind randomized phase III clinical study of treatment of rheumatoid arthritis with recombinant interferon-gamma.

Authors:  E M Lemmel; D Brackertz; M Franke; W Gaus; P W Hartl; K Machalke; H Mielke; H J Obert; H H Peter; J Sieper
Journal:  Rheumatol Int       Date:  1988       Impact factor: 2.631

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Authors:  D M Fastenberg; K R Diddie; K Dorey; S J Ryan
Journal:  Am J Ophthalmol       Date:  1982-05       Impact factor: 5.258

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Authors:  R D Granstein; G F Murphy; R J Margolis; M H Byrne; E P Amento
Journal:  J Clin Invest       Date:  1987-04       Impact factor: 14.808

9.  The antiproliferative effect of interferon and the mitogenic activity of growth factors are independent cell cycle events. Studies with vascular smooth muscle cells and endothelial cells.

Authors:  A D Heyns; A Eldor; I Vlodavsky; N Kaiser; R Fridman; A Panet
Journal:  Exp Cell Res       Date:  1985-12       Impact factor: 3.905

10.  Platelet-derived growth factor is chemotactic for human retinal pigment epithelial cells.

Authors:  P A Campochiaro; B M Glaser
Journal:  Arch Ophthalmol       Date:  1985-04
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  1 in total

1.  In vitro vitamin K3 effect on conjunctival fibroblast migration and proliferation.

Authors:  I Pinilla; L B Izaguirre; F J Gonzalvo; E Piazuelo; M A Garcia-Gonzalez; A I Sanchez-Cano; F Sopeña
Journal:  ScientificWorldJournal       Date:  2014-01-08
  1 in total

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