Literature DB >> 15477662

Induction of RNA interference in dendritic cells.

Mu Li1, Hua Qian, Thomas E Ichim, Wei-Wen Ge, Igor A Popov, Katarzyna Rycerz, John Neu, David White, Robert Zhong, Wei-Ping Min.   

Abstract

Dendritic cells (DC) reside at the center of the immunological universe, possessing the ability both to stimulate and inhibit various types of responses. Tolerogenic/regulatory DC with therapeutic properties can be generated through various means of manipulations in vitro and in vivo. Here we describe several attractive strategies for manipulation of DC using the novel technique of RNA interference (RNAi). Additionally, we overview some of our data regarding yet undescribed characteristics of RNAi in DC such as specific transfection strategies, persistence of gene silencing, and multi-gene silencing. The advantages of using RNAi for DC genetic manipulation gives rise to the promise of generating tailor-made DC that can be used effectively to treat a variety of immunologically mediated diseases.

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Year:  2004        PMID： 15477662     DOI： 10.1385/IR:30:2:215

Source DB:  PubMed          Journal:  Immunol Res        ISSN： 0257-277X            Impact factor:   2.829


  86 in total

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