| Literature DB >> 15477044 |
Sacha Y Boomkens1, Johannes G Kusters, Gaby Hoffmann, Raymond G J Pot, Bart Spee, Louis C Penning, Herman F Egberink, Ted S G A M van den Ingh, Jan Rothuizen.
Abstract
Lymphocytic cholangitis (LC) in cats is a biliary disease of unknown etiology. Helicobacter spp. were recently implicated in human primary sclerosing cholangitis (PSC) and primary biliary cirrhosis (PBC). Because of the similarities between PSC/PBC with LC, we hypothesized that Helicobacter spp. are involved in feline LC. A PCR with Helicobacter genus-specific 16S rRNA primers was performed on DNA isolated from feline bile samples. Four of the 15 (26%) LC samples were positive, whereas only 8/51 (16%) of non-LC samples were PCR positive (p=0.44). Sequence analysis of the amplicons revealed a 100% identity with the Helicobacter pylori specific DNA fragments. Our data suggest an etiological role of H. pylori in feline LC and that cats are a potential zoonotic reservoir.Entities:
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Year: 2004 PMID： 15477044 DOI： 10.1016/j.femsim.2004.06.002
Source DB: PubMed Journal: FEMS Immunol Med Microbiol ISSN： 0928-8244