Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Synthesis and potent antimicrobial activity of some novel 4-(5, 6-dichloro-1H-benzimidazol-2-yl)-N-substituted benzamides.

Literature DB >> 15476288

Synthesis and potent antimicrobial activity of some novel 4-(5, 6-dichloro-1H-benzimidazol-2-yl)-N-substituted benzamides.

Seçkin Ozden¹, Hacer Karataş, Sulhiye Yildiz, Hakan Göker.

Abstract

A series of 4-(5, 6-dichloro-1H-benzimidazol-2-yl)-N-substituted benzamides were synthesized and evaluated for antibacterial and antifungal activities against Staphylococcus aureus, methicillin-resistant S. aureus (MRSA), methicillin-resistant S. epidermis (MRSE), Enterococcus faecalis, Escherichia coli and Candida albicans. Certain compounds inhibit bacterial growth with low MIC values (microg/mL). Among them, compounds 10 and 11 exhibited the greatest antibacterial activity with MIC values of 3.12 microg/mL against S. aureus, MRSA and MRSE.

Entities: Chemical Species

Mesh：

Substances：

Year: 2004 PMID： 15476288 DOI： 10.1002/ardp.200400884

Source DB: PubMed Journal: Arch Pharm (Weinheim) ISSN： 0365-6233 Impact factor: 3.751

Keyword Cloud
Cited

5 in total

Synthesis and potent antimicrobial activity of some novel 4-(5, 6-dichloro-1H-benzimidazol-2-yl)-N-substituted benzamides.

1. Nucleophilic Aromatic Substitution, A Guided Inquiry Laboratory Experiment.

2. 2-(1H-Benzimidazol-1-yl)-1-phenyl-ethanone.

3. Ethyl 1-sec-butyl-2-(4-fluoro-phen-yl)-1H-benzimidazole-5-carboxyl-ate.

4. Crystal structure of 2-(4-chloro-3-fluoro-phen-yl)-1H-benzimidazole.

5. 2-[4-(Tri-fluoro-meth-yl)phen-yl]-1H-benzimidazole.