Literature DB >> 15472947

RNA is more UV resistant than DNA: the formation of UV-induced DNA lesions is strongly sequence and conformation dependent.

Lal Mohan Kundu1, Uwe Linne, Mohamed Marahiel, Thomas Carell.   

Abstract

DNA and RNA hairpins, which represent well-folded oligonucleotide structures, were irradiated and the amount of damaged hairpins was directly quantified by using ion-exchange HPLC. The types of photoproducts formed in the hairpins were determined by ESI-HPLC-MS/MS experiments. Irradiation of hairpins with systematically varied sequences and conformations (A versus B) revealed remarkable differences regarding the amount of photolesions formed. UV-damage formation is, therefore, a strongly sequence and conformation dependent process.

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Year:  2004        PMID： 15472947     DOI： 10.1002/chem.200305731

Source DB:  PubMed          Journal:  Chemistry        ISSN： 0947-6539            Impact factor:   5.236


  11 in total

1.  Thymine dimerization in DNA is an ultrafast photoreaction.

Authors:  Wolfgang J Schreier; Tobias E Schrader; Florian O Koller; Peter Gilch; Carlos E Crespo-Hernández; Vijay N Swaminathan; Thomas Carell; Wolfgang Zinth; Bern Kohler
Journal:  Science       Date:  2007-02-02       Impact factor: 47.728

2.  Structure of a protein-DNA complex essential for DNA protection in spores of Bacillus species.

Authors:  Ki Seog Lee; Daniela Bumbaca; Jeffrey Kosman; Peter Setlow; Mark J Jedrzejas
Journal:  Proc Natl Acad Sci U S A       Date:  2008-02-19       Impact factor: 11.205

3.  Reverse Transcription Past Products of Guanine Oxidation in RNA Leads to Insertion of A and C opposite 8-Oxo-7,8-dihydroguanine and A and G opposite 5-Guanidinohydantoin and Spiroiminodihydantoin Diastereomers.

Authors:  Anton Alenko; Aaron M Fleming; Cynthia J Burrows
Journal:  Biochemistry       Date:  2017-09-11       Impact factor: 3.162

4.  Defective removal of ribonucleotides from DNA promotes systemic autoimmunity.

Authors:  Claudia Günther; Barbara Kind; Martin A M Reijns; Nicole Berndt; Manuel Martinez-Bueno; Christine Wolf; Victoria Tüngler; Osvaldo Chara; Young Ae Lee; Norbert Hübner; Louise Bicknell; Sophia Blum; Claudia Krug; Franziska Schmidt; Stefanie Kretschmer; Sarah Koss; Katy R Astell; Georgia Ramantani; Anja Bauerfeind; David L Morris; Deborah S Cunninghame Graham; Doryen Bubeck; Andrea Leitch; Stuart H Ralston; Elizabeth A Blackburn; Manfred Gahr; Torsten Witte; Timothy J Vyse; Inga Melchers; Elisabeth Mangold; Markus M Nöthen; Martin Aringer; Annegret Kuhn; Kirsten Lüthke; Leonore Unger; Annette Bley; Alice Lorenzi; John D Isaacs; Dimitra Alexopoulou; Karsten Conrad; Andreas Dahl; Axel Roers; Marta E Alarcon-Riquelme; Andrew P Jackson; Min Ae Lee-Kirsch
Journal:  J Clin Invest       Date:  2014-12-15       Impact factor: 14.808

Review 5.  RNAi as a Foliar Spray: Efficiency and Challenges to Field Applications.

Authors:  Bao Tram L Hoang; Stephen J Fletcher; Christopher A Brosnan; Amol B Ghodke; Narelle Manzie; Neena Mitter
Journal:  Int J Mol Sci       Date:  2022-06-14       Impact factor: 6.208

6.  Thymine photodimer formation in DNA hairpins. Unusual conformations favor (6 - 4) vs. (2 + 2) adducts.

Authors:  Mahesh Hariharan; Karsten Siegmund; Clifton Saurel; Martin McCullagh; George C Schatz; Frederick D Lewis
Journal:  Photochem Photobiol Sci       Date:  2014-02       Impact factor: 3.982

7.  Sequence-dependent thymine dimer formation and photoreversal rates in double-stranded DNA.

Authors:  Yu Kay Law; Robert A Forties; Xin Liu; Michael G Poirier; Bern Kohler
Journal:  Photochem Photobiol Sci       Date:  2013-08       Impact factor: 3.982

8.  High-resolution crystal structure of the intramolecular d(TpA) thymine-adenine photoadduct and its mechanistic implications.

Authors:  R Jeremy H Davies; John F Malone; Yu Gan; Christine J Cardin; Michael P H Lee; Stephen Neidle
Journal:  Nucleic Acids Res       Date:  2007-01-30       Impact factor: 16.971

9.  Effect of UV Radiation on Fluorescent RNA Aptamers' Functional and Templating Ability.

Authors:  Ranajay Saha; Irene A Chen
Journal:  Chembiochem       Date:  2019-08-21       Impact factor: 3.164

Review 10.  Nucleic Acid Catalysis under Potential Prebiotic Conditions.

Authors:  Kristian Le Vay; Elia Salibi; Emilie Y Song; Hannes Mutschler
Journal:  Chem Asian J       Date:  2019-12-09
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