| Literature DB >> 15472107 |
James W Simpkins1, Shao-Hua Yang, Ran Liu, Evelyn Perez, Zu Yun Cai, Douglas F Covey, Pattie S Green.
Abstract
We have synthesized a library of estrogen analogues, including enantiomers of estradiol and A-ring substituted estrogens. These compounds have reduced or no binding to either estrogen receptor-alpha or estrogen receptor-beta, exhibit enhanced neuroprotective activity in in vitro models, and are potent in protecting brain tissue from cerebral ischemia/reperfusion injury. These potent, nonfeminizing estrogen analogues are prime candidates for use in stroke neuroprotection.Entities:
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Year: 2004 PMID： 15472107 DOI： 10.1161/01.STR.0000143734.59507.88
Source DB: PubMed Journal: Stroke ISSN： 0039-2499 Impact factor: 7.914