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Literature DB >> 17336390

Structure-nongenomic neuroprotection relationship of estrogens and estrogen-derived compounds.

Abstract

Nongenomic estrogen signaling pathways involve extranuclear estrogen receptors or function independently from estrogen receptors. These pathways participate in neuroprotection elicited by the hormone. Additional nongenomic neuroprotective effects are attributable to antioxidant and antiinflammatory actions of estrogens. Numerous chemical modifications to afford neuroprotective compounds from estrogens while eliminating estrogenicity and maintaining or enhancing nongenomic neuroprotection have been described. This review highlights recent structure-activity studies that revealed the importance of antioxidant effects for neuroprotective estrogen analogues and derivatives.

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Year: 2007 PMID： 17336390 PMCID： PMC1905848 DOI： 10.1016/j.pharmthera.2007.01.006

Source DB: PubMed Journal: Pharmacol Ther ISSN： 0163-7258 Impact factor: 12.310

91 in total

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Authors: B Moosmann; C Behl
Journal: Proc Natl Acad Sci U S A Date: 1999-08-03 Impact factor: 11.205

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Journal: Menopause Date: 2001 Jul-Aug Impact factor: 2.953

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Journal: Crit Rev Eukaryot Gene Expr Date: 2002 Impact factor: 1.807

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Authors: Shao-Hua Yang; Ran Liu; Evelyn J Perez; Yi Wen; Stanley M Stevens; Thomas Valencia; Anne-Marie Brun-Zinkernagel; Laszlo Prokai; Yvonne Will; James Dykens; Peter Koulen; James W Simpkins
Journal: Proc Natl Acad Sci U S A Date: 2004-03-15 Impact factor: 11.205

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Authors: J E Packer; T F Slater; R L Willson
Journal: Nature Date: 1979-04-19 Impact factor: 49.962

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Authors: H Vedder; N Anthes; G Stumm; C Würz; C Behl; J C Krieg
Journal: J Neurochem Date: 1999-06 Impact factor: 5.372

8. Involvement of insulin/phosphoinositide 3-kinase/Akt signal pathway in 17 beta-estradiol-mediated neuroprotection.

Authors: Xiaorui Yu; Raju V S Rajala; James F McGinnis; Feng Li; Robert E Anderson; Xiaorong Yan; Sheng Li; Rajesh V Elias; Ryan R Knapp; Xiaohong Zhou; Wei Cao
Journal: J Biol Chem Date: 2004-01-06 Impact factor: 5.157

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Authors: Matti J Tikkanen; Veera Vihma; Matti Jauhiainen; Anna Höckerstedt; Hannamaarit Helisten; Maija Kaamanen
Journal: Cardiovasc Res Date: 2002-11 Impact factor: 10.787

Review 10. Neurodegenerative diseases and oxidative stress.

Authors: Kevin J Barnham; Colin L Masters; Ashley I Bush
Journal: Nat Rev Drug Discov Date: 2004-03 Impact factor: 84.694

40 in total

1. Effects of multiple daily genistein treatments on delayed alternation and a differential reinforcement of low rates of responding task in middle-aged rats.

Authors: Steven L Neese; Suren B Bandara; Daniel R Doerge; William G Helferich; Donna L Korol; Susan L Schantz
Journal: Neurotoxicol Teratol Date: 2011-09-14 Impact factor: 3.763

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Authors: E B Engler-Chiurazzi; C M Brown; J M Povroznik; J W Simpkins
Journal: Prog Neurobiol Date: 2016-02-15 Impact factor: 11.685

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Authors: Glenda E Gillies; Simon McArthur
Journal: Pharmacol Rev Date: 2010-04-14 Impact factor: 25.468

4. "All in the mind"? Brain-targeting chemical delivery system of 17β-estradiol (Estredox) produces significant uterotrophic side effect.

Authors: Katalin Prokai-Tatrai; Szabolcs Szarka; Vien Nguyen; Fatima Sahyouni; Cary Walker; Shastazia White; Tatjana Talamantes; Laszlo Prokai
Journal: Pharm Anal Acta Date: 2012

5. Postinjury administration of 17β-estradiol induces protection in the gray and white matter with associated functional recovery after cervical spinal cord injury in male rats.

Authors: Akkradate Siriphorn; Kelly A Dunham; Supin Chompoopong; Candace L Floyd
Journal: J Comp Neurol Date: 2012-08-15 Impact factor: 3.215

6. Tonic Premarin dose-dependently enhances memory, affects neurotrophin protein levels and alters gene expression in middle-aged rats.

Authors: Elizabeth Engler-Chiurazzi; Candy Tsang; Sean Nonnenmacher; Winnie S Liang; Jason J Corneveaux; Laszlo Prokai; Matthew J Huentelman; Heather A Bimonte-Nelson
Journal: Neurobiol Aging Date: 2009-11-02 Impact factor: 4.673

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Authors: J M Westberry; A K Prewitt; M E Wilson
Journal: Neuroscience Date: 2008-02-08 Impact factor: 3.590