| Literature DB >> 15471565 |
Dorte Strøbaek1, Lene Teuber, Tino D Jørgensen, Philip K Ahring, Katrine Kjaer, Rie S Hansen, Søren Peter Olesen, Palle Christophersen, Bo Skaaning-Jensen.
Abstract
We have identified and characterized the compound NS309 (6,7-dichloro-1H-indole-2,3-dione 3-oxime) as a potent activator of human Ca2+ -activated K+ channels of SK and IK types, whereas it is devoid of effect on BK type channels. IK- and SK-channels have previously been reported to be activated by the benzimidazolinone, 1-EBIO and more potently by its dichloronated-analogue, DC-EBIO. NS309 is at least 1000 times more potent than 1-EBIO and at least 30 times more potent than DC-EBIO when the compounds are compared on the same cell.Entities:
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Year: 2004 PMID： 15471565 DOI： 10.1016/j.bbamem.2004.07.006
Source DB: PubMed Journal: Biochim Biophys Acta ISSN： 0006-3002