| Literature DB >> 15464450 |
Abstract
Rearrangements of the MLL gene, which is located at chromosome 11q23, are associated with aggressive acute leukemias in both children and adults. MLL regulates Hox gene expression through direct promoter binding and histone modification. MLL rearrangements occurring in leukemia include MLL fusion genes, partial tandem duplications of MLL and MLL amplification. MLL fusions and amplification upregulate Hox expression, apparently resulting in a block of hematopoietic differentiation. Future therapies for MLL-associated leukemia might involve blocking Hox gene upregulation by using fusion proteins or inhibiting the activity of Hox proteins themselves.Entities:
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Year: 2004 PMID： 15464450 DOI： 10.1016/j.molmed.2004.08.005
Source DB: PubMed Journal: Trends Mol Med ISSN： 1471-4914 Impact factor: 11.951