OBJECTIVE: To investigate whether determination of a set of laboratory markers at baseline provides prognostic information on joint damage in hands and feet in rheumatoid arthritis. METHODS: 183 patients with early rheumatoid arthritis included in a prospective study were examined. Radiographic changes in hands and feet at 5 and 10 years after inclusion were evaluated (Larsen). The markers analysed were: erythrocyte sedimentation rate (ESR); HLA-DRB alleles typed by restriction fragment length polymorphism; and C reactive protein, cartilage oligomeric matrix protein (COMP), rheumatoid factor (RF) (IgG, IgA, and IgM subtypes), antibodies against cyclic citrullinated peptide (anti-CCP), and antibodies against interleukin 1alpha (anti-IL1alpha), analysed by immunoassays. Multiple linear regression with backward elimination was used to determine the prognostic value of the variables. RESULTS: 117/176 patients were positive for IgG RF, 138/176 for IgA RF, 139/176 for IgM RF, 140/176 for anti-CCP, and 40/182 for anti-IL1alpha. After five years, ESR, the presence of IgA RF, serum COMP, and the presence of anti-CCP were significantly associated with more severe joint damage, and the presence of anti-IL1alpha with less severe joint damage. Baseline C reactive protein and anti-CCP predicted radiographic outcome after 10 years. A stronger prediction was obtained by combining the prognostic factors. CONCLUSIONS: Early determination of anti-CCP, IgA RF, anti-IL-1alpha, ESR, C reactive protein, and COMP predicted the development of joint damage in hands and feet in this cohort. A combination of these measures reflecting different aspects of the disease process should be useful for evaluating prognosis in individual patients with early rheumatoid arthritis.
OBJECTIVE: To investigate whether determination of a set of laboratory markers at baseline provides prognostic information on joint damage in hands and feet in rheumatoid arthritis. METHODS: 183 patients with early rheumatoid arthritis included in a prospective study were examined. Radiographic changes in hands and feet at 5 and 10 years after inclusion were evaluated (Larsen). The markers analysed were: erythrocyte sedimentation rate (ESR); HLA-DRB alleles typed by restriction fragment length polymorphism; and C reactive protein, cartilage oligomeric matrix protein (COMP), rheumatoid factor (RF) (IgG, IgA, and IgM subtypes), antibodies against cyclic citrullinated peptide (anti-CCP), and antibodies against interleukin 1alpha (anti-IL1alpha), analysed by immunoassays. Multiple linear regression with backward elimination was used to determine the prognostic value of the variables. RESULTS: 117/176 patients were positive for IgG RF, 138/176 for IgA RF, 139/176 for IgM RF, 140/176 for anti-CCP, and 40/182 for anti-IL1alpha. After five years, ESR, the presence of IgA RF, serum COMP, and the presence of anti-CCP were significantly associated with more severe joint damage, and the presence of anti-IL1alpha with less severe joint damage. Baseline C reactive protein and anti-CCP predicted radiographic outcome after 10 years. A stronger prediction was obtained by combining the prognostic factors. CONCLUSIONS: Early determination of anti-CCP, IgA RF, anti-IL-1alpha, ESR, C reactive protein, and COMP predicted the development of joint damage in hands and feet in this cohort. A combination of these measures reflecting different aspects of the disease process should be useful for evaluating prognosis in individual patients with early rheumatoid arthritis.
Authors: B Combe; M Dougados; P Goupille; A Cantagrel; J F Eliaou; J Sibilia; O Meyer; J Sany; J P Daurès; A Dubois Journal: Arthritis Rheum Date: 2001-08
Authors: L R Lard; M Boers; A Verhoeven; K Vos; H Visser; J M W Hazes; A H Zwinderman; G M T Schreuder; F C Breedveld; R R P De Vries; S van der Linden; E Zanelli; T W J Huizinga Journal: Arthritis Rheum Date: 2002-04
Authors: E Larsson; H Erlandsson Harris; J C Lorentzen; A Larsson; B Månsson; L Klareskog; T Saxne Journal: Rheumatology (Oxford) Date: 2002-09 Impact factor: 7.580
Authors: O Meyer; C Labarre; M Dougados; Ph Goupille; A Cantagrel; A Dubois; P Nicaise-Roland; J Sibilia; B Combe Journal: Ann Rheum Dis Date: 2003-02 Impact factor: 19.103
Authors: Elena Nikiphorou; Lewis Carpenter; Sam Norton; Stephen Morris; Alex MacGregor; Josh Dixey; Peter Williams; Patrick Kiely; David Andrew Walsh; Adam Young Journal: Curr Rheumatol Rep Date: 2017-03 Impact factor: 4.592
Authors: Roger R Beerli; Monika Bauer; Andrea Fritzer; Lindsey B Rosen; Regula B Buser; Markus Hanner; Melanie Maudrich; Mario Nebenfuehr; Jorge Alejandro Sepulveda Toepfer; Susanne Mangold; Anton Bauer; Steven M Holland; Sarah K Browne; Andreas Meinke Journal: MAbs Date: 2014 Impact factor: 5.857
Authors: Benedicte A Lie; Marte K Viken; Sigrid Odegård; Désirée van der Heijde; Robert Landewé; Till Uhlig; Tore K Kvien Journal: Ann Rheum Dis Date: 2007-05-01 Impact factor: 19.103
Authors: João Luiz Coelho Ribas; Shirley Ramos da Rosa Utiyama; Renato Mitsunori Nisihara; Maristela Boeira; Iara Taborda de Messias Reason Journal: Rheumatol Int Date: 2008-09-27 Impact factor: 2.631