| Literature DB >> 15458501 |
J J Doel1, M P Hector, C V Amirtham, L A Al-Anzan, N Benjamin, R P Allaker.
Abstract
To test the hypothesis that a combination of high salivary nitrate and high nitrate-reducing capacity are protective against dental caries, 209 children attending the Dental Institute, Barts and The London NHS Trust were examined. Salivary nitrate and nitrite levels, counts of Streptococcus mutans and Lactobacillus spp., and caries experience were recorded. Compared with control subjects, a significant reduction in caries experience was found in patients with high salivary nitrate and high nitrate-reducing ability. Production of nitrite from salivary nitrate by commensal nitrate-reducing bacteria may limit the growth of cariogenic bacteria as a result of the production of antimicrobial oxides of nitrogen, including nitric oxide.Entities:
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Year: 2004 PMID： 15458501 DOI： 10.1111/j.1600-0722.2004.00153.x
Source DB: PubMed Journal: Eur J Oral Sci ISSN： 0909-8836 Impact factor: 2.612