M Syed1,2, V Sachdev3,4, R Chopra3,4. 1. ITS Centre for Dental Studies and Research, Delhi-Meerut Road, Muradnagar, Ghaziabad, 201206, India. meenasyed10@yahoo.com. 2. Department of Pedodontics, ITS-CDSR Centre for Dental Studies and Research, Muradnagar, Ghaziabad, 201206, India. meenasyed10@yahoo.com. 3. ITS Centre for Dental Studies and Research, Delhi-Meerut Road, Muradnagar, Ghaziabad, 201206, India. 4. Department of Pedodontics, ITS-CDSR Centre for Dental Studies and Research, Muradnagar, Ghaziabad, 201206, India.
Abstract
AIM: To determine the efficacy of salivary nitric oxide as a biomarker for dental caries risk in children and to compare the salivary nitric oxide levels in caries-active and caries-free children. METHODS: One hundred children aged 6-12 years were selected and were divided into two groups according to DMFT index: as caries-free consisting of 50 individuals (DMFT/dmft = 0) and caries-active group (DMFT/dmft ≥3) consisting of 50 individuals. The saliva collected was estimated for nitric oxide level by Griess reaction method. Paired t test was used to correlate the difference of mean salivary nitric oxide levels between caries-active and caries-free groups. RESULTS: The mean level of nitric oxide in saliva of the control group was 581.3 ± 134.6 μg/mL and that of caries-active group was 335.4 ± 111.1 μg/mL, respectively. The mean salivary level of nitric oxide was higher in the caries-free group as compared with the caries-active group which was statistically significant (p = 0.000). CONCLUSIONS: Salivary nitric oxide was higher in the caries-free group as compared to the caries-active group which suggests that increased production of nitric oxide in the oral cavity may contribute to lower caries incidence in children.
AIM: To determine the efficacy of salivary nitric oxide as a biomarker for dental caries risk in children and to compare the salivary nitric oxide levels in caries-active and caries-free children. METHODS: One hundred children aged 6-12 years were selected and were divided into two groups according to DMFT index: as caries-free consisting of 50 individuals (DMFT/dmft = 0) and caries-active group (DMFT/dmft ≥3) consisting of 50 individuals. The saliva collected was estimated for nitric oxide level by Griess reaction method. Paired t test was used to correlate the difference of mean salivary nitric oxide levels between caries-active and caries-free groups. RESULTS: The mean level of nitric oxide in saliva of the control group was 581.3 ± 134.6 μg/mL and that of caries-active group was 335.4 ± 111.1 μg/mL, respectively. The mean salivary level of nitric oxide was higher in the caries-free group as compared with the caries-active group which was statistically significant (p = 0.000). CONCLUSIONS: Salivary nitric oxide was higher in the caries-free group as compared to the caries-active group which suggests that increased production of nitric oxide in the oral cavity may contribute to lower caries incidence in children.
Authors: S Carossa; P Pera; P Doglio; S Lombardo; P Colagrande; L Brussino; G Rolla; C Bucca Journal: Eur J Clin Invest Date: 2001-10 Impact factor: 4.686
Authors: H Kojima; N Nakatsubo; K Kikuchi; S Kawahara; Y Kirino; H Nagoshi; Y Hirata; T Nagano Journal: Anal Chem Date: 1998-07-01 Impact factor: 6.986