AIMS: To describe the association between age and risk factors in patients hospitalised with congestive heart failure (CHF) and to determine the effect of age on mortality. METHODS AND RESULTS:Consecutive patients admitted to 34 hospitals with CHF during a period of 2 years were registered. Mean age was 71.7+/-10.2 years, 60% were male and 63% were in NYHA class III-IV. Moderate to severe left ventricular (LV) systolic dysfunction was present in 41%. Short and long-term survival status was obtained after 30 days and 5-8 years, respectively. Older patients less frequently had LV systolic dysfunction, were under treated with ACE-inhibitors and were more often female. The prevalence of hypertension, diabetes and ischaemic heart disease increased with age, until the oldest age group (>80 years). Age was an independent predictor of short-term mortality (risk ratio (RR) per 10-year increase was 1.23 (95% CI 1.04-1.47)). Advancing age significantly increased long-term mortality (RR 1.55 (1.50-1.61)). Age interacted with the LV ejection fraction (P = 0.003). In patients with LV systolic dysfunction, the RR per 10-year increase was 1.29 (1.19-1.39) whereas in patients with preserved systolic function the RR was 1.57 (1.43-1.72, multivariate analyses). CONCLUSION: The clinical characteristics of CHF patients vary considerably with age. Elderly patients hospitalised with CHF face a very grave prognosis, particularly if their heart failure symptoms are caused by LV systolic dysfunction.
RCT Entities:
AIMS: To describe the association between age and risk factors in patients hospitalised with congestive heart failure (CHF) and to determine the effect of age on mortality. METHODS AND RESULTS: Consecutive patients admitted to 34 hospitals with CHF during a period of 2 years were registered. Mean age was 71.7+/-10.2 years, 60% were male and 63% were in NYHA class III-IV. Moderate to severe left ventricular (LV) systolic dysfunction was present in 41%. Short and long-term survival status was obtained after 30 days and 5-8 years, respectively. Older patients less frequently had LV systolic dysfunction, were under treated with ACE-inhibitors and were more often female. The prevalence of hypertension, diabetes and ischaemic heart disease increased with age, until the oldest age group (>80 years). Age was an independent predictor of short-term mortality (risk ratio (RR) per 10-year increase was 1.23 (95% CI 1.04-1.47)). Advancing age significantly increased long-term mortality (RR 1.55 (1.50-1.61)). Age interacted with the LV ejection fraction (P = 0.003). In patients with LV systolic dysfunction, the RR per 10-year increase was 1.29 (1.19-1.39) whereas in patients with preserved systolic function the RR was 1.57 (1.43-1.72, multivariate analyses). CONCLUSION: The clinical characteristics of CHFpatients vary considerably with age. Elderly patients hospitalised with CHF face a very grave prognosis, particularly if their heart failure symptoms are caused by LV systolic dysfunction.
Authors: Nathaniel Mark Hawkins; Mark C Petrie; Pardeep S Jhund; George W Chalmers; Francis G Dunn; John J V McMurray Journal: Eur J Heart Fail Date: 2009-02 Impact factor: 15.534
Authors: Justin T Parizo; Jeremy D Goldhaber-Fiebert; Joshua A Salomon; Kiran K Khush; John A Spertus; Paul A Heidenreich; Alexander T Sandhu Journal: JAMA Cardiol Date: 2021-08-01 Impact factor: 30.154
Authors: Anne Delgado; Bruno Rodrigues; Sara Nunes; Rui Baptista; Bruno Marmelo; Davide Moreira; Pedro Gama; Luís Nunes; Oliveira Santos; Costa Cabral Journal: Arq Bras Cardiol Date: 2016-12 Impact factor: 2.000
Authors: Alexander T Sandhu; Jeremy D Goldhaber-Fiebert; Douglas K Owens; Mintu P Turakhia; Daniel W Kaiser; Paul A Heidenreich Journal: JACC Heart Fail Date: 2016-02-10 Impact factor: 12.544
Authors: Philip Andrew Quinones; Inge Kirchberger; Margit Heier; Bernhard Kuch; Ines Trentinaglia; Andreas Mielck; Annette Peters; Wolfgang von Scheidt; Christa Meisinger Journal: BMC Public Health Date: 2014-01-30 Impact factor: 3.295