Literature DB >> 1544543

Radiation burdens for humans on prolonged exomagnetospheric voyages.

F D Moore1.   

Abstract

The severity of radiation exposure for astronauts outside the magnetosphere poses a critical unanswered question bearing on the use of manned vehicles in extended exploration of the solar system (moon, Mars). Such prolonged exomagnetospheric voyages (1-3 years) enter a radiologic environment more severe than that of low earth orbit, an annual dose equivalent in the range of 0.3-0.5 Sv (30-50 rem), and a lifetime excess cancer fatality risk of 3-5% due to low linear-energy-transfer components of galactic cosmic radiation alone. To this calculus must be added estimates for high-atomic-number, high-energy particles, the probability of solar particle events, and the limited effectiveness of shielding. For a 3-year Mars voyage these could elevate the dose equivalent to 1.5-2.25 Sv (150-225 rem) total (0.5-0.75 Sv [50-75 rem] annual) and risks to 5-9% excess cancer fatality. Both the mission (civilian scientific research) and the alternatives (unmanned robotic devices) enter the policy decision here. This paper presents a brief review of pertinent physical and biological data and of research urgently needed before reaching a decision on this question.

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Year:  1992        PMID: 1544543     DOI: 10.1096/fasebj.6.6.1544543

Source DB:  PubMed          Journal:  FASEB J        ISSN: 0892-6638            Impact factor:   5.191


  5 in total

1.  Whole-body proton irradiation causes long-term damage to hematopoietic stem cells in mice.

Authors:  Jianhui Chang; Wei Feng; Yingying Wang; Yi Luo; Antiño R Allen; Igor Koturbash; Jennifer Turner; Blair Stewart; Jacob Raber; Martin Hauer-Jensen; Daohong Zhou; Lijian Shao
Journal:  Radiat Res       Date:  2015-01-30       Impact factor: 2.841

2.  Behavioral consequences of radiation exposure to simulated space radiation in the C57BL/6 mouse: open field, rotorod, and acoustic startle.

Authors:  Michael J Pecaut; Paul Haerich; Cara N Zuccarelli; Anna L Smith; Eric D Zendejas; Gregory A Nelson
Journal:  Cogn Affect Behav Neurosci       Date:  2002-12       Impact factor: 3.282

3.  Peptone stimulates CCK-releasing peptide secretion by activating intestinal submucosal cholinergic neurons.

Authors:  Y Li; C Owyang
Journal:  J Clin Invest       Date:  1996-03-15       Impact factor: 14.808

4.  mFISH analysis of chromosomal damage in bone marrow cells collected from CBA/CaJ mice following whole body exposure to heavy ions (56Fe ions).

Authors:  K Noy Rithidech; L Honikel; E B Whorton
Journal:  Radiat Environ Biophys       Date:  2007-02-14       Impact factor: 2.017

5.  Proton irradiation impacts age-driven modulations of cancer progression influenced by immune system transcriptome modifications from splenic tissue.

Authors:  Justin Wage; Lili Ma; Michael Peluso; Clare Lamont; Andrew M Evens; Philip Hahnfeldt; Lynn Hlatky; Afshin Beheshti
Journal:  J Radiat Res       Date:  2015-08-07       Impact factor: 2.724

  5 in total

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