BACKGROUND: Little is known about the occurrence of specific congenital malformations among offspring of mixed race-ethnicity. METHODS: Using data from a population-based registry, we explored the occurrence of selected malformation phenotypes in offspring to parents who were of different race-ethnicity. Data were derived from the California Birth Defects Monitoring Program, a population-based active surveillance system for collecting information on infants and fetuses with congenital malformations using multiple source ascertainment. Approximately 2.6 million live births and stillbirths occurred during 1989-2000. Information on parental race-ethnicity (non-Hispanic white, Hispanic, black, and Asian) was obtained from birth certificates and fetal death files. Malformation phenotypes studied were spina bifida, anencephaly, cleft lip, cleft palate, tetralogy of Fallot, d-transposition of great arteries, hypospadias, small intestinal atresia, preaxial polydactyly, microtia, and hypertrophic pyloric stenosis. RESULTS: A total of 11.2% of births were to parents of mixed race-ethnicity. Compared to births of parents who were both white, moderately increased risks (risk ratio >/= 1.7) of anencephaly, polydactyly, and microtia, and decreased risks (risk ratio </= 0.6) of hypospadias and hypertrophic pyloric stenosis were observed among births of several mixed race-ethnicity groups. For anencephaly, polydactyly, and microtia, but not other phenotypes, the risks were different depending on whether maternal versus paternal race-ethnicity was considered. Risks observed between births of a nonwhite parent and a white parent and births of parents who were both nonwhite were similar for most malformation phenotypes. CONCLUSIONS: Some malformation phenotypes appear to vary in their risk based on mixed racial-ethnic groupings. (c) 2004 Wiley-Liss, Inc.
BACKGROUND: Little is known about the occurrence of specific congenital malformations among offspring of mixed race-ethnicity. METHODS: Using data from a population-based registry, we explored the occurrence of selected malformation phenotypes in offspring to parents who were of different race-ethnicity. Data were derived from the California Birth Defects Monitoring Program, a population-based active surveillance system for collecting information on infants and fetuses with congenital malformations using multiple source ascertainment. Approximately 2.6 million live births and stillbirths occurred during 1989-2000. Information on parental race-ethnicity (non-Hispanic white, Hispanic, black, and Asian) was obtained from birth certificates and fetal death files. Malformation phenotypes studied were spina bifida, anencephaly, cleft lip, cleft palate, tetralogy of Fallot, d-transposition of great arteries, hypospadias, small intestinal atresia, preaxial polydactyly, microtia, and hypertrophic pyloric stenosis. RESULTS: A total of 11.2% of births were to parents of mixed race-ethnicity. Compared to births of parents who were both white, moderately increased risks (risk ratio >/= 1.7) of anencephaly, polydactyly, and microtia, and decreased risks (risk ratio </= 0.6) of hypospadias and hypertrophic pyloric stenosis were observed among births of several mixed race-ethnicity groups. For anencephaly, polydactyly, and microtia, but not other phenotypes, the risks were different depending on whether maternal versus paternal race-ethnicity was considered. Risks observed between births of a nonwhite parent and a white parent and births of parents who were both nonwhite were similar for most malformation phenotypes. CONCLUSIONS: Some malformation phenotypes appear to vary in their risk based on mixed racial-ethnic groupings. (c) 2004 Wiley-Liss, Inc.
Authors: Daniela V Luquetti; Matthew L Speltz; Erin R Wallace; Babette Siebold; Brent R Collett; Amelia F Drake; Alexis L Johns; Kathleen A Kapp-Simon; Sara L Kinter; Brian G Leroux; Leanne Magee; Susan Norton; Kathleen Sie; Carrie L Heike Journal: Cleft Palate Craniofac J Date: 2019-01-08
Authors: Marisa A Ryan; Andrew F Olshan; Mark A Canfield; Adrienne T Hoyt; Angela E Scheuerle; Suzan L Carmichael; Gary M Shaw; Martha M Werler; Sarah C Fisher; Tania A Desrosiers Journal: Int J Pediatr Otorhinolaryngol Date: 2019-03-23 Impact factor: 1.675
Authors: Daniela V Luquetti; Carrie L Heike; Anne V Hing; Michael L Cunningham; Timothy C Cox Journal: Am J Med Genet A Date: 2011-11-21 Impact factor: 2.802
Authors: Daniela V Luquetti; Babette S Saltzman; Jorge Lopez-Camelo; Maria da Graça Dutra; Eduardo E Castilla Journal: Birth Defects Res A Clin Mol Teratol Date: 2013-11
Authors: Adrienne T Hoyt; Mark A Canfield; Gary M Shaw; Dorothy K Waller; Kara N D Polen; Tunu Ramadhani; Marlene T Anderka; Angela E Scheuerle Journal: Birth Defects Res A Clin Mol Teratol Date: 2014-07-30