| Literature DB >> 15388155 |
Gautam Panda1, Jitendra Kumar Mishra, Vinita Chaturvedi, Anil K Srivastava, Ranjana Srivastava, Brahm S Srivastava.
Abstract
A new series of diaryloxy methano phenanthrenes were prepared through tertiary-aminoalkylations of [(methoxy-phenyl)-phenanthren-9-yl-methyl]-phenols obtained from Friedel-Crafts alkylations on (methoxy-phenyl)-phenanthren-9-yl-methanols. These series of compounds were evaluated against Mycobacterium tuberculosis H37Rv and showed the desired activity in the range of 6.25 microg/mL in vitro. One of the compound 12j protects the mice from the challenge of M. tuberculosis in vivo, as 30% of the mice were survived at treatment of 50 mg/kg body weight.Entities:
Mesh：
Substances：
Year: 2004 PMID： 15388155 DOI： 10.1016/j.bmc.2004.07.058
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641