Literature DB >> 15380215

Biaryl guanidine inhibitors of in vitro HCV-IRES activity.

Elizabeth A Jefferson1, Punit P Seth, Dale E Robinson, Dana K Winter, Alycia Miyaji, Stephen A Osgood, Eric E Swayze, Lisa M Risen.   

Abstract

A structure-activity relationship analysis was carried out on a high-throughput small molecule screening lead for HCV-IRES translation inhibition. The study led to the identification of a guanidine-based structure with low microM inhibitory activity.

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Year:  2004        PMID: 15380215     DOI: 10.1016/j.bmcl.2004.07.066

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN: 0960-894X            Impact factor:   2.823


  7 in total

1.  Integration of high accuracy N-terminus identification in peptide sequencing and comparative protein analysis via isothiocyanate-based isotope labeling reagent with ESI ion-trap TOF MS.

Authors:  Jiapeng Leng; Haoyang Wang; Li Zhang; Jing Zhang; Hang Wang; Tingting Cai; Jinting Yao; Yinlong Guo
Journal:  J Am Soc Mass Spectrom       Date:  2011-04-15       Impact factor: 3.109

Review 2.  Synthetic small-molecule RNA ligands: future prospects as therapeutic agents.

Authors:  A Di Giorgio; M Duca
Journal:  Medchemcomm       Date:  2019-04-30       Impact factor: 3.597

3.  Selection of cyclic peptide aptamers to HCV IRES RNA using mRNA display.

Authors:  Alexander Litovchick; Jack W Szostak
Journal:  Proc Natl Acad Sci U S A       Date:  2008-09-29       Impact factor: 11.205

Review 4.  Hepatitis C virus translation inhibitors targeting the internal ribosomal entry site.

Authors:  Sergey M Dibrov; Jerod Parsons; Maia Carnevali; Shu Zhou; Kevin D Rynearson; Kejia Ding; Emily Garcia Sega; Nicholas D Brunn; Mark A Boerneke; Maria P Castaldi; Thomas Hermann
Journal:  J Med Chem       Date:  2013-11-05       Impact factor: 7.446

5.  Systematic analysis of the interactions driving small molecule-RNA recognition.

Authors:  G Padroni; N N Patwardhan; M Schapira; A E Hargrove
Journal:  RSC Med Chem       Date:  2020-06-04

Review 6.  Small molecules targeting viral RNA.

Authors:  Thomas Hermann
Journal:  Wiley Interdiscip Rev RNA       Date:  2016-06-16       Impact factor: 9.957

Review 7.  Targeting RNA structures with small molecules.

Authors:  Jessica L Childs-Disney; Xueyi Yang; Quentin M R Gibaut; Yuquan Tong; Robert T Batey; Matthew D Disney
Journal:  Nat Rev Drug Discov       Date:  2022-08-08       Impact factor: 112.288

  7 in total

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