Literature DB >> 1537876

Functional regulation of osteoblastic cells by the interaction of activin-A with follistatin.

M Hashimoto1, A Shoda, S Inoue, R Yamada, T Kondo, T Sakurai, N Ueno, M Muramatsu.   

Abstract

A high number of 125I-activin-A binding sites (an apparent Kd of 260 pM and 5,600 sites/cell) were observed on MC3T3-E1 cells, a well characterized osteoblastic cell line. Activin-A has a mitogenic effect on these cells, with the greatest influence being observed on cells in an undifferentiated state, as well as a suppressive effect on the alkaline phosphatase activity. Northern and ligand blotting analyses revealed that these osteoblastic cells produce follistatin, which was down-regulated by retinoic acid treatment. Because follistatin is an activin-A-binding protein, we suggest that activin-A modulates the function of osteoblastic cells by being regulated by follistatin during differentiation.

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Year:  1992        PMID： 1537876

Source DB:  PubMed          Journal:  J Biol Chem        ISSN： 0021-9258            Impact factor:   5.157


  17 in total

Review 1.  Novel therapeutic targets in myeloma bone disease.

Authors:  S L Webb; C M Edwards
Journal:  Br J Pharmacol       Date:  2014-08       Impact factor: 8.739

Review 2.  TGF-β Family Signaling in Mesenchymal Differentiation.

Authors:  Ingo Grafe; Stefanie Alexander; Jonathan R Peterson; Taylor Nicholas Snider; Benjamin Levi; Brendan Lee; Yuji Mishina
Journal:  Cold Spring Harb Perspect Biol       Date:  2018-05-01       Impact factor: 10.005

3.  Expression of immunoreactive activin A protein in remodeling lesions associated with interstitial pulmonary fibrosis.

Authors:  T Matsuse; A Ikegami; E Ohga; T Hosoi; T Oka; K Kida; M Fukayama; S Inoue; T Nagase; Y Ouchi; Y Fukuchi
Journal:  Am J Pathol       Date:  1996-03       Impact factor: 4.307

4.  Stimulation of activin A expression in rat aortic smooth muscle cells by thrombin and angiotensin II correlates with neointimal formation in vivo.

Authors:  J E Pawlowski; D S Taylor; M Valentine; M E Hail; P Ferrer; M C Kowala; C J Molloy
Journal:  J Clin Invest       Date:  1997-08-01       Impact factor: 14.808

5.  Virtual High-Throughput Screening To Identify Novel Activin Antagonists.

Authors:  Jie Zhu; Rama K Mishra; Gary E Schiltz; Yogeshwar Makanji; Karl A Scheidt; Andrew P Mazar; Teresa K Woodruff
Journal:  J Med Chem       Date:  2015-07-07       Impact factor: 7.446

6.  Activin A expression regulates multipotency of mesenchymal progenitor cells.

Authors:  Farida Djouad; Wesley M Jackson; Brent E Bobick; Sasa Janjanin; Yingjie Song; George T J Huang; Rocky S Tuan
Journal:  Stem Cell Res Ther       Date:  2010-05-04       Impact factor: 6.832

7.  Bone morphogenetic proteins induce the expression of noggin, which limits their activity in cultured rat osteoblasts.

Authors:  E Gazzerro; V Gangji; E Canalis
Journal:  J Clin Invest       Date:  1998-12-15       Impact factor: 14.808

8.  Biochemical properties of amphibian bone morphogenetic protein-4 expressed in CHO cells.

Authors:  A Suzuki; S Nishimatsu; A Shoda; K Takebayashi; K Murakami; N Ueno
Journal:  Biochem J       Date:  1993-04-15       Impact factor: 3.857

9.  Circulating activin-A is elevated in postmenopausal women with low bone mass: the three-month effect of zoledronic acid treatment.

Authors:  A D Anastasilakis; S A Polyzos; P Makras; A Gkiomisi; M Savvides; A Papatheodorou; E Terpos
Journal:  Osteoporos Int       Date:  2012-11-03       Impact factor: 4.507

10.  Autoinduction of activin genes in early Xenopus embryos.

Authors:  A Suzuki; T Nagai; S Nishimatsu; H Sugino; Y Eto; H Shibai; K Murakami; N Ueno
Journal:  Biochem J       Date:  1994-03-01       Impact factor: 3.857
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