Literature DB >> 15378039

Interneurons of the neocortical inhibitory system.

Henry Markram1, Maria Toledo-Rodriguez, Yun Wang, Anirudh Gupta, Gilad Silberberg, Caizhi Wu.   

Abstract

Mammals adapt to a rapidly changing world because of the sophisticated cognitive functions that are supported by the neocortex. The neocortex, which forms almost 80% of the human brain, seems to have arisen from repeated duplication of a stereotypical microcircuit template with subtle specializations for different brain regions and species. The quest to unravel the blueprint of this template started more than a century ago and has revealed an immensely intricate design. The largest obstacle is the daunting variety of inhibitory interneurons that are found in the circuit. This review focuses on the organizing principles that govern the diversity of inhibitory interneurons and their circuits.

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Year:  2004        PMID： 15378039     DOI： 10.1038/nrn1519

Source DB:  PubMed          Journal:  Nat Rev Neurosci        ISSN： 1471-003X            Impact factor:   34.870


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