| Literature DB >> 15378020 |
Atsushi Niida1, Takatoshi Hiroko, Mana Kasai, Yoichi Furukawa, Yusuke Nakamura, Yutaka Suzuki, Sumio Sugano, Tetsu Akiyama.
Abstract
Wnt signaling plays an important role in embryonic development and tumorigenesis. These biological effects are exerted by activation of the beta-catenin/TCF transcription complex and consequent regulation of a set of downstream genes. TCF-binding elements have been found in the promoter regions of many TCF target genes and characterized by a highly conserved consensus sequence. Utilizing this consensus sequence, we performed an in silico screening for new TCF target genes. Through computational screening and subsequent experimental analysis, we identified a novel TCF target gene, DKK1, which has been shown to be a potent inhibitor of Wnt signaling. Our finding suggests the existence of a novel feedback loop in Wnt signaling.Entities:
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Year: 2004 PMID： 15378020 DOI： 10.1038/sj.onc.1207892
Source DB: PubMed Journal: Oncogene ISSN： 0950-9232 Impact factor: 9.867