| Literature DB >> 15377787 |
Xinmin Zhang1, Matthew Rogers, Huikai Tian, Xiaohong Zhang, Dong-Jing Zou, Jian Liu, Minghong Ma, Gordon M Shepherd, Stuart J Firestein.
Abstract
The large number of olfactory receptor genes necessitates high throughput methods to analyze their expression patterns. We have therefore designed a high-density oligonucleotide array containing all known mouse olfactory receptor (OR) and V1R vomeronasal receptor genes. This custom array detected a large number of receptor genes, demonstrating specific expression in the olfactory sensory epithelium for approximately 800 OR genes previously designated as ORs based solely on genomic sequences. The array also enabled us to monitor the spatial and temporal distribution of gene expression for the entire OR family. Interestingly, OR genes showing spatially segregated expression patterns were also segregated on the chromosomes. This correlation between genomic location and spatial expression provides unique insights about the regulation of this large family of genes.Entities:
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Year: 2004 PMID： 15377787 PMCID： PMC521132 DOI： 10.1073/pnas.0405350101
Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205