Literature DB >> 1537623

Differential expression of the CD44 molecule in human brain tumours.

M C Kuppner1, E Van Meir, T Gauthier, M F Hamou, N de Tribolet.   

Abstract

Expression of the CD44 molecule was examined in a variety of human brain tumours, brain metastases and normal brain. Immunohistological staining with several CD44 antibodies demonstrated differential expression of the CD44 molecule among different brain tumour types. CD44 was strongly expressed in high-grade gliomas and weakly expressed in meningiomas, medulloblastomas and normal brain. Northern blot analysis revealed the presence of 3 major CD44 mRNAs of 1.6, 2.2, and 5.0 kb in glioblastomas and a mRNA of 5.6 kb in meningiomas. CD44 expression was also detected by flow cytometric analysis on cultured cells derived from a variety of human brain tumours including glioblastomas and meningiomas.

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Year:  1992        PMID： 1537623     DOI： 10.1002/ijc.2910500414

Source DB:  PubMed          Journal:  Int J Cancer        ISSN： 0020-7136            Impact factor:   7.396


  27 in total

1.  The distribution of extracellular matrix proteins and CD44S expression in human astrocytomas.

Authors:  B Oz; F A Karayel; N L Gazio; F Ozlen; K Balci
Journal:  Pathol Oncol Res       Date:  2000       Impact factor: 3.201

2.  The interaction between CD44 on tumour cells and hyaluronan under physiologic flow conditions: implications for metastasis formation.

Authors:  Ulrich Richter; Daniel Wicklein; Silvana Geleff; Udo Schumacher
Journal:  Histochem Cell Biol       Date:  2012-01-24       Impact factor: 4.304

3.  Detachment of transformed cells. Role of CD44 variants.

Authors:  C Santos; K Chandler; S Zimmer; P B Fisher; U Gunthert; K W Anderson
Journal:  Cell Biophys       Date:  1995-02

Review 4.  Forms and functions of CD44.

Authors:  G Borland; J A Ross; K Guy
Journal:  Immunology       Date:  1998-02       Impact factor: 7.397

Review 5.  Expression of the CD44 adhesion molecule in tumours of the central and peripheral nervous system.

Authors:  G H Baltuch; N de Tribolet; E G Van Meir
Journal:  J Neurooncol       Date:  1995-12       Impact factor: 4.130

6.  Hyaluronate receptors mediating glioma cell migration and proliferation.

Authors:  Y Akiyama; S Jung; B Salhia; S Lee; S Hubbard; M Taylor; T Mainprize; K Akaishi; W van Furth; J T Rutka
Journal:  J Neurooncol       Date:  2001-06       Impact factor: 4.130

Review 7.  Biological mechanisms of glioma invasion and potential therapeutic targets.

Authors:  B B Tysnes; R Mahesparan
Journal:  J Neurooncol       Date:  2001-06       Impact factor: 4.130

8.  CD44 exon 6 expression as a possible early prognostic factor in primary node negative breast carcinoma.

Authors:  N Guriec; L Marcellin; B Gairard; H Caldéroli; A Wilk; R Renaud; J P Bergerat; F Oberling
Journal:  Clin Exp Metastasis       Date:  1996-10       Impact factor: 5.150

9.  Expression of cell adhesion molecules alpha-2, alpha-5 and alpha-6 integrin, E-cadherin, N-CAM and CD-44 in renal cell carcinomas. An immunohistochemical study.

Authors:  H J Terpe; K Tajrobehkar; U Günthert; M Altmannsberger
Journal:  Virchows Arch A Pathol Anat Histopathol       Date:  1993

10.  The hyaluronan receptor RHAMM/IHABP in astrocytoma cells: expression of a tumor-specific variant and association with microtubules.

Authors:  Rixin Zhou; Xiao Wu; Omar Skalli
Journal:  J Neurooncol       Date:  2002-08       Impact factor: 4.130
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