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Literature DB >> 8493778

Expression of cell adhesion molecules alpha-2, alpha-5 and alpha-6 integrin, E-cadherin, N-CAM and CD-44 in renal cell carcinomas. An immunohistochemical study.

H J Terpe¹, K Tajrobehkar, U Günthert, M Altmannsberger.

Abstract

Renal cell carcinoma is known to metastasize early independent of tumour grade. Invasion of the renal vein plays an important role in the prognosis. Cell adhesion molecules have been investigated, including the expression of alpha-2, alpha-5, and alpha-6 integrin, E-cadherin, neural-cell adhesion molecule and CD-44 in 34 renal cell carcinomas, using the alkaline phosphatase-anti-alkaline phosphatase technique. Our results indicate a differential expression of these cell adhesion molecules (alpha-2, alpha-5 and E-cadherin) depending on histological type and tumour grade.

Entities: Disease Gene

Mesh：

Substances：

Year: 1993 PMID： 8493778 DOI： 10.1007/BF01621805

Source DB: PubMed Journal: Virchows Arch A Pathol Anat Histopathol ISSN： 0174-7398

23 in total

Review 1. Integrins and tumor invasion.

Authors: S Dedhar
Journal: Bioessays Date: 1990-12 Impact factor: 4.345

Review 2. Integrins in developing, normal and malignant human kidney.

Authors: M Korhonen; L Laitinen; J Ylänne; V E Gould; I Virtanen
Journal: Kidney Int Date: 1992-03 Impact factor: 10.612

3. E-cadherin expression in squamous cell carcinomas of head and neck: inverse correlation with tumor dedifferentiation and lymph node metastasis.

Authors: J H Schipper; U H Frixen; J Behrens; A Unger; K Jahnke; W Birchmeier
Journal: Cancer Res Date: 1991-12-01 Impact factor: 12.701

4. Neural cell adhesion molecule: structure, immunoglobulin-like domains, cell surface modulation, and alternative RNA splicing.

Authors: B A Cunningham; J J Hemperly; B A Murray; E A Prediger; R Brackenbury; G M Edelman
Journal: Science Date: 1987-05-15 Impact factor: 47.728

5. Characterization of the class III collagen receptor, a phosphorylated, transmembrane glycoprotein expressed in nucleated human cells.

Authors: W G Carter; E A Wayner
Journal: J Biol Chem Date: 1988-03-25 Impact factor: 5.157

6. Renal cell carcinoma: comparison of morphological and flow cytometric parameters of primary tumour and invasive tumour lying within the renal vein.

Authors: M R Novelli; A G MacIver
Journal: J Pathol Date: 1992-06 Impact factor: 7.996

7. Histopathology and classification of renal cell tumors (adenomas, oncocytomas and carcinomas). The basic cytological and histopathological elements and their use for diagnostics.

Authors: W Thoenes; S Störkel; H J Rumpelt
Journal: Pathol Res Pract Date: 1986-05 Impact factor: 3.250

8. The A9 antigen associated with aggressive human squamous carcinoma is structurally and functionally similar to the newly defined integrin alpha 6 beta 4.

Authors: C Van Waes; K F Kozarsky; A B Warren; L Kidd; D Paugh; M Liebert; T E Carey
Journal: Cancer Res Date: 1991-05-01 Impact factor: 12.701

Review 9. The Walter Herbert Lecture. Control of cell motility and tumour invasion by extracellular matrix interactions.

Authors: E Ruoslahti
Journal: Br J Cancer Date: 1992-08 Impact factor: 7.640

10. Distinct effects of two CD44 isoforms on tumor growth in vivo.

Authors: M S Sy; Y J Guo; I Stamenkovic
Journal: J Exp Med Date: 1991-10-01 Impact factor: 14.307

13 in total

1. Expression of CD44 isoforms in human renal cell carcinomas.

Authors: K H Heider; M Ratschek; K Zatloukal; G R Adolf
Journal: Virchows Arch Date: 1996-07 Impact factor: 4.064

Review 2. Molecular variants of fibronectin and laminin: structure, physiological occurrence and histopathological aspects.

Authors: H Kosmehl; A Berndt; D Katenkamp
Journal: Virchows Arch Date: 1996-12 Impact factor: 4.064

Expression of cell adhesion molecules alpha-2, alpha-5 and alpha-6 integrin, E-cadherin, N-CAM and CD-44 in renal cell carcinomas. An immunohistochemical study.

Review 1. Integrins and tumor invasion.

Review 2. Integrins in developing, normal and malignant human kidney.

3. E-cadherin expression in squamous cell carcinomas of head and neck: inverse correlation with tumor dedifferentiation and lymph node metastasis.

4. Neural cell adhesion molecule: structure, immunoglobulin-like domains, cell surface modulation, and alternative RNA splicing.

5. Characterization of the class III collagen receptor, a phosphorylated, transmembrane glycoprotein expressed in nucleated human cells.

6. Renal cell carcinoma: comparison of morphological and flow cytometric parameters of primary tumour and invasive tumour lying within the renal vein.

7. Histopathology and classification of renal cell tumors (adenomas, oncocytomas and carcinomas). The basic cytological and histopathological elements and their use for diagnostics.

8. The A9 antigen associated with aggressive human squamous carcinoma is structurally and functionally similar to the newly defined integrin alpha 6 beta 4.

Review 9. The Walter Herbert Lecture. Control of cell motility and tumour invasion by extracellular matrix interactions.

10. Distinct effects of two CD44 isoforms on tumor growth in vivo.

1. Expression of CD44 isoforms in human renal cell carcinomas.

Review 2. Molecular variants of fibronectin and laminin: structure, physiological occurrence and histopathological aspects.

3. Expression of cell adhesion molecules and common acute lymphoblastic leukaemia antigen in hepatoblastoma.

Review 4. Biology of metastasis and its clinical implications: renal-cell cancer.

Review 5. The E-cadherin cell-cell adhesion pathway in urologic malignancies.

6. Expression of CD44 3'-untranslated region regulates endogenous microRNA functions in tumorigenesis and angiogenesis.

7. Expression of CD44 isoforms in renal cell tumors. Positive correlation to tumor differentiation.

8. Expression and ligand binding of alpha 2 beta 1 integrin on breast carcinoma cells.

9. Integrins and extracellular matrix-proteins in the different components of the Wilms' tumour.

10. E-cadherin expression in renal cell cancer and its significance in metastasis and survival.