| Literature DB >> 15374666 |
Abstract
A genetic screen for resistance to ethanol intoxication in Caenorhabditis elegans isolated mutants of the gene slo-1. slo-1 encodes the pore-forming subunit of a large-conductance Ca(2+)-activated K(+) channel previously shown to limit excitatory neurotransmitter release in C. elegans. Electrophysiological data recorded in vivo are consistent with a model in which ethanol potentiation of SLO-1 produces intoxication in C. elegans by reducing excitatory neurotransmitter release.Entities:
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Year: 2004 PMID： 15374666 DOI： 10.1016/j.tins.2004.07.006
Source DB: PubMed Journal: Trends Neurosci ISSN： 0166-2236 Impact factor: 13.837