OBJECTIVE: Early onset disorders may have more salient familial/genetic etiology. Neurocognitive deficits which are seen in families of adult onset schizophrenic patients were examined in healthy family members of patients with childhood-onset schizophrenia (COS). METHODS: Trail Making Tests (TMT) A and B, Wechsler Intelligence Scale-Revised Digit Span and Vocabulary subtests were administered to 67 parents and 24 siblings of patients with childhood-onset schizophrenia and 114 healthy community controls (CC) comparable in sex, age, and educational level. RESULTS: COS siblings performed significantly more poorly than did controls on Trails Making Test B with a trend for poorer performance evident on Trails Making Test A. COS parents performed more poorly than controls only on Trails Making Test A. CONCLUSIONS: Healthy first-degree relatives of COS probands have subtle deficits in tests involving oculomotor/psychomotor speed, working memory and executive function. This provides further support for continuity between COS and later onset schizophrenia and for a familial/genetic factor associated with the illness.
OBJECTIVE: Early onset disorders may have more salient familial/genetic etiology. Neurocognitive deficits which are seen in families of adult onset schizophrenicpatients were examined in healthy family members of patients with childhood-onset schizophrenia (COS). METHODS: Trail Making Tests (TMT) A and B, Wechsler Intelligence Scale-Revised Digit Span and Vocabulary subtests were administered to 67 parents and 24 siblings of patients with childhood-onset schizophrenia and 114 healthy community controls (CC) comparable in sex, age, and educational level. RESULTS: COS siblings performed significantly more poorly than did controls on Trails Making Test B with a trend for poorer performance evident on Trails Making Test A. COS parents performed more poorly than controls only on Trails Making Test A. CONCLUSIONS: Healthy first-degree relatives of COS probands have subtle deficits in tests involving oculomotor/psychomotor speed, working memory and executive function. This provides further support for continuity between COS and later onset schizophrenia and for a familial/genetic factor associated with the illness.
Authors: M Mallar Chakravarty; Judith L Rapoport; Jay N Giedd; Armin Raznahan; Philip Shaw; D Louis Collins; Jason P Lerch; Nitin Gogtay Journal: Hum Brain Mapp Date: 2014-12-11 Impact factor: 5.038
Authors: Anand A Mattai; Brian Weisinger; Deanna Greenstein; Reva Stidd; Liv Clasen; Rachel Miller; Julia W Tossell; Judith L Rapoport; Nitin Gogtay Journal: J Am Acad Child Adolesc Psychiatry Date: 2011-06-11 Impact factor: 8.829
Authors: Frances F Loeb; Xueping Zhou; Kirsten E S Craddock; Lorie Shora; Diane D Broadnax; Peter Gochman; Liv S Clasen; Francois M Lalonde; Rebecca A Berman; Karen F Berman; Judith L Rapoport; Siyuan Liu Journal: J Am Acad Child Adolesc Psychiatry Date: 2017-12-28 Impact factor: 8.829
Authors: S Kristian Hill; Margret S H Harris; Ellen S Herbener; Mani Pavuluri; John A Sweeney Journal: Schizophr Bull Date: 2008-04-29 Impact factor: 9.306