Literature DB >> 15374228

Al, Zn, Cu, Mn and Fe levels in brain in Alzheimer's disease.

E Andrási1, E Farkas, H Scheibler, A Réffy, L Bezúr.   

Abstract

The aim of our experiments was to investigate the possible element concentration changes in Alzheimer's disease. Our project incorporated the determination of the regional distribution of elements in normal human brain, too. Five elements (Al, Zn, Cu, Mn and Fe) have been measured in 10 different regions of 20 normal brains (mean age 70 years) and in brain parts of patients with Alzheimer's disease (9 individuals). Analyses were carried out by inductively coupled plasma atomic emission spectrometry (ICP-AES) and instrumental neutron activation analysis (INAA) techniques. Analytical precision and accuracy were investigated by NIST standard reference material. In a comparison between the healthy and Alzheimer patients' concentration data using statistical treatment these elements showed difference as a function of the Alzheimer disease (AD).

Entities:  

Year:  1995        PMID： 15374228     DOI： 10.1016/0167-4943(95)00643-y

Source DB:  PubMed          Journal:  Arch Gerontol Geriatr        ISSN： 0167-4943            Impact factor:   3.250


  24 in total

1.  Selective, quantitative measurement of releasable synaptic zinc in human autopsy hippocampal brain tissue from Alzheimer's disease patients.

Authors:  Nicole L Bjorklund; V-M Sadagoparamanujam; Giulio Taglialatela
Journal:  J Neurosci Methods       Date:  2011-09-16       Impact factor: 2.390

Review 2.  Human health risk assessment for aluminium, aluminium oxide, and aluminium hydroxide.

Authors:  Daniel Krewski; Robert A Yokel; Evert Nieboer; David Borchelt; Joshua Cohen; Jean Harry; Sam Kacew; Joan Lindsay; Amal M Mahfouz; Virginie Rondeau
Journal:  J Toxicol Environ Health B Crit Rev       Date:  2007       Impact factor: 6.393

3.  Iron, zinc and copper in the Alzheimer's disease brain: a quantitative meta-analysis. Some insight on the influence of citation bias on scientific opinion.

Authors:  Matthew Schrag; Claudius Mueller; Udochukwu Oyoyo; Mark A Smith; Wolff M Kirsch
Journal:  Prog Neurobiol       Date:  2011-05-11       Impact factor: 11.685

Review 4.  Treating Alzheimer's disease by targeting iron.

Authors:  Sara Nikseresht; Ashley I Bush; Scott Ayton
Journal:  Br J Pharmacol       Date:  2019-02-11       Impact factor: 8.739

Review 5.  A potential role for zinc alterations in the pathogenesis of Alzheimer's disease.

Authors:  Ganna Lyubartseva; Mark A Lovell
Journal:  Biofactors       Date:  2012-03-23       Impact factor: 6.113

6.  Embedding carbon dots and gold nanoclusters in metal-organic frameworks for ratiometric fluorescence detection of Cu2.

Authors:  Qingqing Tan; Ruirui Zhang; Guoyan Zhang; Xiaoya Liu; Fengli Qu; Limin Lu
Journal:  Anal Bioanal Chem       Date:  2020-01-11       Impact factor: 4.142

Review 7.  The Complex Role of Apolipoprotein E in Alzheimer's Disease: an Overview and Update.

Authors:  Laura Mahoney-Sanchez; Abdel Ali Belaidi; Ashley I Bush; Scott Ayton
Journal:  J Mol Neurosci       Date:  2016-09-19       Impact factor: 3.444

8.  Multi-element Analysis of Brain Regions from South African Cadavers.

Authors:  Karen Cilliers; Christo J F Muller
Journal:  Biol Trace Elem Res       Date:  2020-05-02       Impact factor: 3.738

Review 9.  Biometals and their therapeutic implications in Alzheimer's disease.

Authors:  Scott Ayton; Peng Lei; Ashley I Bush
Journal:  Neurotherapeutics       Date:  2015-01       Impact factor: 7.620

10.  Demonstration of an olfactory bulb-brain translocation pathway for ZnO nanoparticles in rodent cells in vitro and in vivo.

Authors:  Yi-Yun Kao; Tsun-Jen Cheng; De-Ming Yang; Chin-Tien Wang; Yin-Mei Chiung; Pei-Shan Liu
Journal:  J Mol Neurosci       Date:  2012-04-15       Impact factor: 3.444
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