BACKGROUND: Since 1995, dual-kidney transplantation using organs from marginal donors has been used at our center to expand the organ donor pool and decrease the waiting time for deceased donor kidney transplantation. This approach has allowed for a shorter waiting period without compromising outcome in the early posttransplant period. We now have 8-year follow-up in the first recipients. Older individuals were offered this option preferentially, because we reasoned that they would stand to benefit most from the shorter waiting period. METHODS: Patients aged 55 years or more who underwent either dual-kidney transplantation with expanded criteria donors or single-kidney transplantation with standard donors were included in this study. All expanded criteria donor organs were those that were refused by all other local transplant centers. The primary endpoints were recipient death and graft failure. RESULTS: Waiting time for dual-kidney transplantation was 440 +/- 38 days versus 664 +/- 51 days for single-kidney transplantation (P<0.01). The 8-year actuarial patient survivals for the single- and dual-kidney transplants were 74.1% and 82.1%, respectively. The 8-year actuarial graft survivals for the single- and dual-kidney transplants were 59.4% and 69.7%, respectively. CONCLUSIONS: Eight-year actuarial patient and graft survivals in older individuals who underwent dual-kidney transplantation are equivalent to those who underwent standard single-kidney transplantation. With the continuing organ shortage and increasing waiting times for cadaver kidney transplantation, dual-kidney transplantation using organs that would otherwise be discarded offers a good option for older individuals who may not withstand a long waiting period.
BACKGROUND: Since 1995, dual-kidney transplantation using organs from marginal donors has been used at our center to expand the organ donor pool and decrease the waiting time for deceased donor kidney transplantation. This approach has allowed for a shorter waiting period without compromising outcome in the early posttransplant period. We now have 8-year follow-up in the first recipients. Older individuals were offered this option preferentially, because we reasoned that they would stand to benefit most from the shorter waiting period. METHODS:Patients aged 55 years or more who underwent either dual-kidney transplantation with expanded criteria donors or single-kidney transplantation with standard donors were included in this study. All expanded criteria donor organs were those that were refused by all other local transplant centers. The primary endpoints were recipient death and graft failure. RESULTS: Waiting time for dual-kidney transplantation was 440 +/- 38 days versus 664 +/- 51 days for single-kidney transplantation (P<0.01). The 8-year actuarial patient survivals for the single- and dual-kidney transplants were 74.1% and 82.1%, respectively. The 8-year actuarial graft survivals for the single- and dual-kidney transplants were 59.4% and 69.7%, respectively. CONCLUSIONS: Eight-year actuarial patient and graft survivals in older individuals who underwent dual-kidney transplantation are equivalent to those who underwent standard single-kidney transplantation. With the continuing organ shortage and increasing waiting times for cadaver kidney transplantation, dual-kidney transplantation using organs that would otherwise be discarded offers a good option for older individuals who may not withstand a long waiting period.
Authors: Robert J Stratta; Michael S Rohr; Aimee K Sundberg; Alan C Farney; Erica L Hartmann; Phillip S Moore; Jeffrey Rogers; Samy S Iskandar; Michael D Gautreaux; David F Kiger; William Doares; Teresa K Anderson; Gloria Hairston; Patricia L Adams Journal: Ann Surg Date: 2006-05 Impact factor: 12.969
Authors: I Gandolfini; C Buzio; P Zanelli; A Palmisano; E Cremaschi; A Vaglio; G Piotti; L Melfa; G La Manna; G Feliciangeli; M Cappuccilli; M P Scolari; I Capelli; L Panicali; O Baraldi; S Stefoni; A Buscaroli; L Ridolfi; A D'Errico; G Cappelli; D Bonucchi; E Rubbiani; A Albertazzi; A Mehrotra; P Cravedi; U Maggiore Journal: Am J Transplant Date: 2014-08-25 Impact factor: 8.086
Authors: Jane C Tan; Biruh Workeneh; Stephan Busque; Kristina Blouch; Geraldine Derby; Bryan D Myers Journal: J Am Soc Nephrol Date: 2008-09-24 Impact factor: 10.121
Authors: Ramesh Saxena; Xueqing Yu; Mauricio Giraldo; Juan Arenas; Miguel Vazquez; Christopher Y Lu; Nosratola D Vaziri; Fred G Silva; Xin J Zhou Journal: Int Urol Nephrol Date: 2008-11-07 Impact factor: 2.370
Authors: B Tanriover; S Mohan; D J Cohen; J Radhakrishnan; T L Nickolas; P W Stone; D S Tsapepas; R J Crew; G K Dube; P R Sandoval; B Samstein; E Dogan; R S Gaston; J N Tanriover; L E Ratner; M A Hardy Journal: Am J Transplant Date: 2014-02 Impact factor: 8.086
Authors: Edmund Q Sanchez; Bernard V Fischbach; Gomathy Narasimhan; Srinath Chinnakotla; Dmitriy Nikitin; Tariq Khan; Henry B Randall; Gregory J McKenna; Richard Ruiz; Robert M Goldstein; Göran B Klintmalm; Marlon F Levy Journal: Proc (Bayl Univ Med Cent) Date: 2007-07
Authors: Carlo Grifasi; Vincenzo D'Alessandro; Maria D'Armiento; Severo Campione; Alessandro Scotti; Luigi Pelosio; Andrea Renda Journal: BMC Nephrol Date: 2014-12-23 Impact factor: 2.388
Authors: Muhammad Abdul Mabood Khalil; Jackson Tan; Taqi F Toufeeq Khan; Muhammad Ashhad Ullah Khalil; Rabeea Azmat Journal: Int Sch Res Notices Date: 2017-07-02