Literature DB >> 15367368

The degenerate Y chromosome--can conversion save it?

Jennifer A Marshall Graves1.   

Abstract

The human Y chromosome is running out of time. In the last 300 million years, it has lost 1393 of its original 1438 genes, and at this rate it will lose the last 45 in a mere 10 million years. But there has been a proposal that perhaps rescue is at hand in the form of recently discovered gene conversion within palindromes. However, I argue here that although conversion will increase the frequency of variation of the Y (particularly amplification) between Y chromosomes in a population, it will not lead to a drive towards a more functional Y. The forces of evolution have made the Y a genetically isolated, non-recombining entity, vulnerable to genetic drift and selection for favourable new variants sharing the Y with damaging mutations. Perhaps it will even speed up the decline of the Y chromosome and the onset of a new round of sex-chromosome differentiation. The struggle to preserve males may perhaps lead to hominid speciation.

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Year:  2004        PMID: 15367368     DOI: 10.10371/RD03096

Source DB:  PubMed          Journal:  Reprod Fertil Dev        ISSN: 1031-3613            Impact factor:   2.311


  12 in total

1.  The temporal dynamics of processes underlying Y chromosome degeneration.

Authors:  Doris Bachtrog
Journal:  Genetics       Date:  2008-06-18       Impact factor: 4.562

2.  The sex with the reduced sex chromosome dies earlier: a comparison across the tree of life.

Authors:  Zoe A Xirocostas; Susan E Everingham; Angela T Moles
Journal:  Biol Lett       Date:  2020-03-04       Impact factor: 3.703

Review 3.  Y-chromosome evolution: emerging insights into processes of Y-chromosome degeneration.

Authors:  Doris Bachtrog
Journal:  Nat Rev Genet       Date:  2013-02       Impact factor: 53.242

4.  A ZZ/ZW microchromosome system in the spiny softshell turtle, Apalone spinifera, reveals an intriguing sex chromosome conservation in Trionychidae.

Authors:  Daleen Badenhorst; Roscoe Stanyon; Tag Engstrom; Nicole Valenzuela
Journal:  Chromosome Res       Date:  2013-03-20       Impact factor: 5.239

5.  Sex differences in the meiotic behavior of an XX sex chromosome pair in males and females of the mole vole Ellobius tancrei: turning an X into a Y chromosome?

Authors:  Ana Gil-Fernández; Sergey Matveevsky; Marta Martín-Ruiz; Marta Ribagorda; María Teresa Parra; Alberto Viera; Julio S Rufas; Oxana Kolomiets; Irina Bakloushinskaya; Jesús Page
Journal:  Chromosoma       Date:  2021-04-06       Impact factor: 4.316

6.  Genomic evolution in Barrett's adenocarcinoma cells: critical roles of elevated hsRAD51, homologous recombination and Alu sequences in the genome.

Authors:  J Pal; R Bertheau; L Buon; A Qazi; R B Batchu; S Bandyopadhyay; R Ali-Fehmi; D G Beer; D W Weaver; R J Shmookler Reis; R K Goyal; Q Huang; N C Munshi; M A Shammas
Journal:  Oncogene       Date:  2011-03-21       Impact factor: 9.867

7.  Can intra-Y gene conversion oppose the degeneration of the human Y chromosome? A simulation study.

Authors:  Gabriel A B Marais; Paulo R A Campos; Isabel Gordo
Journal:  Genome Biol Evol       Date:  2010-07-12       Impact factor: 3.416

8.  Functional networking of human divergently paired genes (DPGs).

Authors:  Bin Xie; Dapeng Wang; Yong Duan; Jun Yu; Hongxing Lei
Journal:  PLoS One       Date:  2013-10-31       Impact factor: 3.240

Review 9.  Sex determination: why so many ways of doing it?

Authors:  Doris Bachtrog; Judith E Mank; Catherine L Peichel; Mark Kirkpatrick; Sarah P Otto; Tia-Lynn Ashman; Matthew W Hahn; Jun Kitano; Itay Mayrose; Ray Ming; Nicolas Perrin; Laura Ross; Nicole Valenzuela; Jana C Vamosi
Journal:  PLoS Biol       Date:  2014-07-01       Impact factor: 8.029

10.  Evolution and survival on eutherian sex chromosomes.

Authors:  Melissa A Wilson; Kateryna D Makova
Journal:  PLoS Genet       Date:  2009-07-17       Impact factor: 5.917

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