Literature DB >> 15365750

The effect of labor and/or ovariectomy on rodent continence mechanism--the neuronal changes.

Karl-Dietrich Sievert1, Mustafa Emre Bakircioglu, Tony Tsai, Lora Nunes, Tom F Lue.   

Abstract

Many women develop stress urinary incontinence (SUI) after childbirth, but the exact neuronal changes are largely unknown. This study is designed to identify the neuronal changes associated with pregnancy, delivery and ovariectomy. A total of 10 virgin and 48 pregnant rats were used. Cystometry and stress/sneeze tests were performed in the virgin once and the pregnant rats at certain time points. Postpartum the rats were equally grouped as follows: group I: delivery, group II: delivery + ballooning, group III: delivery + ovariectomy, group IV: delivery + ballooning + ovariectomy. Tissues from bladder, bladder neck, and urethra were analyzed by immunostaining for PGP 9.5, CGRP, SP, NPY, VIP, TH, n-NOS. We found complex innervation changes in the different tissue samples. Since the bladder neck and the mid-urethra play an important role in the continence mechanism the neuronal changes in these areas contribute to the observed functional changes.

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Mesh：

Year:  2004        PMID： 15365750     DOI： 10.1007/s00345-004-0444-6

Source DB:  PubMed          Journal:  World J Urol        ISSN： 0724-4983            Impact factor:   4.226


  30 in total

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Journal:  Science       Date:  1992-07-17       Impact factor: 47.728

2.  Distribution of neuropeptide-, tyrosine hydroxylase- and nitric oxide synthase containing nerve fibers in the external urethral sphincter of the rat.

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Review 3.  Nitric oxide synthase and the lower urinary tract: possible implications for physiology and pathophysiology.

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Journal:  Scand J Urol Nephrol Suppl       Date:  1995

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Authors:  S Jackson; A Shepherd; S Brookes; P Abrams
Journal:  Br J Obstet Gynaecol       Date:  1999-07

5.  The effect of pregnancy and delivery on the function and ultrastructure of the rat bladder and urethra.

Authors:  M E Bakircioglu; K D Sievert; A Lau; C S Lin; T F Lue
Journal:  BJU Int       Date:  2000-02       Impact factor: 5.588

6.  Nitric oxide synthase--its distribution and alteration in the intramural ganglia of the urinary bladder in normal and urethra-obstructed guinea pigs.

Authors:  Y Zhou; E A Ling
Journal:  Ann Acad Med Singapore       Date:  1999-01       Impact factor: 2.473

7.  The visualisation of cardiovascular innervation in the guinea pig using an antiserum to protein gene product 9.5 (PGP 9.5).

Authors:  S Gulbenkian; J Wharton; J M Polak
Journal:  J Auton Nerv Syst       Date:  1987-03

8.  Co-existence of nitrergic, peptidergic and acetylcholine esterase-positive nerves in the pig lower urinary tract.

Authors:  K Persson; P Alm; K Johansson; B Larsson; K E Andersson
Journal:  J Auton Nerv Syst       Date:  1995-04-08

9.  Effect of simulated birth trauma on the urinary continence mechanism in the rat.

Authors:  A S Lin; S Carrier; D M Morgan; T F Lue
Journal:  Urology       Date:  1998-07       Impact factor: 2.649

10.  Sympathetic and sensory innervation of the urinary tract in young adult and aged rats: a semi-quantitative histochemical and immunohistochemical study.

Authors:  A L Warburton; R M Santer
Journal:  Histochem J       Date:  1994-02
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  10 in total

1.  Increased duration of simulated childbirth injuries results in increased time to recovery.

Authors:  H Q Pan; J M Kerns; D L Lin; S Liu; N Esparza; M S Damaser
Journal:  Am J Physiol Regul Integr Comp Physiol       Date:  2007-01-04       Impact factor: 3.619

2.  Ex vivo biomechanical, functional, and immunohistochemical alterations of adrenergic responses in the female urethra in a rat model of birth trauma.

Authors:  Rachelle Prantil-Baun; William C de Groat; Minoru Miyazato; Michael B Chancellor; Naoki Yoshimura; David A Vorp
Journal:  Am J Physiol Renal Physiol       Date:  2010-05-05

Review 3.  Animal models of stress urinary incontinence.

Authors:  Hai-Hong Jiang; Margot S Damaser
Journal:  Handb Exp Pharmacol       Date:  2011

4.  Role of vasoactive intestinal peptide and pituitary adenylate cyclase activating polypeptide in the vaginal wall of women with stress urinary incontinence and pelvic organ prolapse.

Authors:  Xinru Hong; Lili Huang; Yanfeng Song
Journal:  Int Urogynecol J Pelvic Floor Dysfunct       Date:  2008-03-20

Review 5.  Animal models of female stress urinary incontinence.

Authors:  Adonis Hijaz; Firouz Daneshgari; Karl-Dietrich Sievert; Margot S Damaser
Journal:  J Urol       Date:  2008-04-18       Impact factor: 7.450

6.  Effect of extended-term estrogen on voiding in a postpartum ovariectomized rat model.

Authors:  Narihiko Hayashi; Anthony J Bella; Guifang Wang; Guiting Lin; Donna Y Deng; Lora Nunes; Tom F Lue
Journal:  Can Urol Assoc J       Date:  2007-09       Impact factor: 1.862

7.  Collagen I:III ratio in canine heterologous bladder acellular matrix grafts.

Authors:  Karl-Dietrich Sievert; Thomas Fandel; Joerg Wefer; Curtis A Gleason; Lora Nunes; Rajvir Dahiya; Emil A Tanagho
Journal:  World J Urol       Date:  2006-02-11       Impact factor: 4.226

Review 8.  Large Animal Models for Investigating Cell Therapies of Stress Urinary Incontinence.

Authors:  Bastian Amend; Niklas Harland; Jasmin Knoll; Arnulf Stenzl; Wilhelm K Aicher
Journal:  Int J Mol Sci       Date:  2021-06-05       Impact factor: 5.923

9.  Synergistic effect of vaginal trauma and ovariectomy in a murine model of stress urinary incontinence: upregulation of urethral nitric oxide synthases and estrogen receptors.

Authors:  Huey-Yi Chen; Wen-Chi Chen; Yu-Ning Lin; Yung-Hsiang Chen
Journal:  Mediators Inflamm       Date:  2014-08-31       Impact factor: 4.711

Review 10.  Stem cell therapy for faecal incontinence: Current state and future perspectives.

Authors:  Jacobo Trébol; Ana Carabias-Orgaz; Mariano García-Arranz; Damián García-Olmo
Journal:  World J Stem Cells       Date:  2018-07-26       Impact factor: 5.326
  10 in total

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