| Literature DB >> 1378650 |
A L Burnett1, C J Lowenstein, D S Bredt, T S Chang, S H Snyder.
Abstract
Nitric oxide (NO) is a cytotoxic agent of macrophages, a messenger molecule of neurons, and a vasodilator produced by endothelial cells. NO synthase, the synthetic enzyme for NO, was localized to rat penile neurons innervating the corpora cavernosa and to neuronal plexuses in the adventitial layer of penile arteries. Small doses of NO synthase inhibitors abolished electrophysiologically induced penile erections. These results establish NO as a physiologic mediator of erectile function.Entities:
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Year: 1992 PMID： 1378650 DOI： 10.1126/science.1378650
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728