Literature DB >> 15365149

APOE-dependent PET patterns of brain activation in Alzheimer disease.

N Scarmeas1, K E Anderson, J Hilton, A Park, C Habeck, J Flynn, B Tycko, Y Stern.   

Abstract

Using H2(15)O PET, the authors imaged 13 patients with Alzheimer disease (AD) while performing a serial nonverbal recognition memory task. Patterns of brain activation differed as a function of APOE genotype: epsilon4 carriers exhibited lower activation in the left lingual gyrus and higher activation in left cuneus, precuneus, parahippocampal, and right precentral gyrus. The APOE genotype seems to play a role in cerebral physiologic activity even after onset of clinical manifestations of AD.

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Year:  2004        PMID： 15365149      PMCID： PMC3026570          DOI： 10.1212/01.wnl.0000137274.93125.46

Source DB:  PubMed          Journal:  Neurology        ISSN： 0028-3878            Impact factor:   9.910


  10 in total

1.  Cognitive reserve modulates functional brain responses during memory tasks: a PET study in healthy young and elderly subjects.

Authors:  Nikolaos Scarmeas; Eric Zarahn; Karen E Anderson; John Hilton; Joseph Flynn; Ronald L Van Heertum; Harold A Sackeim; Yaakov Stern
Journal:  Neuroimage       Date:  2003-07       Impact factor: 6.556

2.  Regional cerebral glucose utilization is modulated by the dosage of apolipoprotein E type 4 allele and alpha1-antichymotrypsin type A allele in Alzheimer's disease.

Authors:  M Higuchi; H Arai; T Nakagawa; S Higuchi; T Muramatsu; S Matsushita; Y Kosaka; M Itoh; H Sasaki
Journal:  Neuroreport       Date:  1997-08-18       Impact factor: 1.837

3.  The absence of an apolipoprotein epsilon4 allele is associated with a more aggressive form of Alzheimer's disease.

Authors:  Y Stern; J Brandt; M Albert; D M Jacobs; X Liu; K Bell; K Marder; M Sano; S Albert; C Del-Castillo Castenada; F Bylsma; B Tycko; R Mayeux
Journal:  Ann Neurol       Date:  1997-05       Impact factor: 10.422

4.  Apolipoprotein E epsilon 4 and the pattern of regional brain atrophy in Alzheimer's disease.

Authors:  M Hashimoto; M Yasuda; S Tanimukai; M Matsui; N Hirono; H Kazui; E Mori
Journal:  Neurology       Date:  2001-10-23       Impact factor: 9.910

5.  Patterns of brain activation in people at risk for Alzheimer's disease.

Authors:  S Y Bookheimer; M H Strojwas; M S Cohen; A M Saunders; M A Pericak-Vance; J C Mazziotta; G W Small
Journal:  N Engl J Med       Date:  2000-08-17       Impact factor: 91.245

Review 6.  Hippocampal atrophy and apolipoprotein E genotype are independently associated with Alzheimer's disease.

Authors:  C R Jack; R C Petersen; Y C Xu; P C O'Brien; S C Waring; E G Tangalos; G E Smith; R J Ivnik; S N Thibodeau; E Kokmen
Journal:  Ann Neurol       Date:  1998-03       Impact factor: 10.422

7.  Association between the APOE genotype and psychopathologic symptoms in Alzheimer's disease.

Authors:  N Scarmeas; J Brandt; M Albert; D P Devanand; K Marder; K Bell; A Ciappa; B Tycko; Y Stern
Journal:  Neurology       Date:  2002-04-23       Impact factor: 9.910

8.  No difference in cerebral glucose metabolism in patients with Alzheimer disease and differing apolipoprotein E genotypes.

Authors:  E H Corder; V Jelic; H Basun; L Lannfelt; S Valind; B Winblad; A Nordberg
Journal:  Arch Neurol       Date:  1997-03

9.  Longitudinal SPECT study in Alzheimer's disease: relation to apolipoprotein E polymorphism.

Authors:  M Lehtovirta; J Kuikka; S Helisalmi; P Hartikainen; A Mannermaa; M Ryynänen; H Soininen
Journal:  J Neurol Neurosurg Psychiatry       Date:  1998-06       Impact factor: 10.154

10.  Apolipoprotein E, dementia, and cortical deposition of beta-amyloid protein.

Authors:  T Polvikoski; R Sulkava; M Haltia; K Kainulainen; A Vuorio; A Verkkoniemi; L Niinistö; P Halonen; K Kontula
Journal:  N Engl J Med       Date:  1995-11-09       Impact factor: 91.245
  10 in total
  15 in total

1.  Failing compensatory mechanisms during working memory in older apolipoprotein E-epsilon4 healthy adults.

Authors:  Francesca M Filbey; Gang Chen; Trey Sunderland; Robert M Cohen
Journal:  Brain Imaging Behav       Date:  2010-06       Impact factor: 3.978

2.  PET is better than perfusion SPECT for early diagnosis of Alzheimer's disease -- for.

Authors:  Kazunari Ishii; Satoshi Minoshima
Journal:  Eur J Nucl Med Mol Imaging       Date:  2005-12       Impact factor: 9.236

3.  Seizures in Alzheimer disease: who, when, and how common?

Authors:  Nikolaos Scarmeas; Lawrence S Honig; Hyunmi Choi; Julio Cantero; Jason Brandt; Deborah Blacker; Marilyn Albert; Joan C Amatniek; Karen Marder; Karen Bell; W Allen Hauser; Yaakov Stern
Journal:  Arch Neurol       Date:  2009-08

4.  Neurodegenerative disease diagnosis using incomplete multi-modality data via matrix shrinkage and completion.

Authors:  Kim-Han Thung; Chong-Yaw Wee; Pew-Thian Yap; Dinggang Shen
Journal:  Neuroimage       Date:  2014-01-27       Impact factor: 6.556

Review 5.  Neurovascular function in Alzheimer's disease patients and experimental models.

Authors:  Nektaria Nicolakakis; Edith Hamel
Journal:  J Cereb Blood Flow Metab       Date:  2011-04-06       Impact factor: 6.200

6.  Altered medial temporal lobe responses during visuospatial encoding in healthy APOE*4 carriers.

Authors:  Paul R Borghesani; L Clark Johnson; Amy L Shelton; Elaine R Peskind; Elizabeth H Aylward; Gerard D Schellenberg; Monique M Cherrier
Journal:  Neurobiol Aging       Date:  2007-03-09       Impact factor: 4.673

7.  Physical activity and Alzheimer disease course.

Authors:  Nikolaos Scarmeas; Jose A Luchsinger; Adam M Brickman; Stephanie Cosentino; Nicole Schupf; Ming Xin-Tang; Yian Gu; Yaakov Stern
Journal:  Am J Geriatr Psychiatry       Date:  2011-05       Impact factor: 4.105

8.  The influence of parental history of Alzheimer's disease and apolipoprotein E epsilon4 on the BOLD signal during recognition memory.

Authors:  Guofan Xu; Donald G McLaren; Michele L Ries; Michele E Fitzgerald; Barbara B Bendlin; Howard A Rowley; Mark A Sager; Craig Atwood; Sanjay Asthana; Sterling C Johnson
Journal:  Brain       Date:  2008-10-01       Impact factor: 13.501

Review 9.  Imaging studies and APOE genotype in persons at risk for Alzheimer's disease.

Authors:  Nikolaos Scarmeas; Yaakov Stern
Journal:  Curr Psychiatry Rep       Date:  2006-02       Impact factor: 5.285

10.  Effects of methylphenidate on resting-state brain activity in normal adults: an fMRI study.

Authors:  Yihong Zhu; Bin Gao; Jianming Hua; Weibo Liu; Yichao Deng; Lijie Zhang; Biao Jiang; Yufeng Zang
Journal:  Neurosci Bull       Date:  2013-01-30       Impact factor: 5.203
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