| Literature DB >> 15364463 |
Janet M Daly1, Philip J Yates, J Richard Newton, Andrew Park, William Henley, James L N Wood, Nick Davis-Poynter, Jennifer A Mumford.
Abstract
Two lineages of antigenically distinct equine influenza A H3N8 subtype viruses, American and European, co-circulate. Experiments were conducted in ponies to investigate the protection induced by vaccines containing virus from one lineage against challenge infection with homologous or heterologous virus. Regression analysis showed that vaccinated ponies with average pre-challenge single radial haemolysis (SRH) antibody levels (i.e. 45-190mm2) had a higher probability of becoming infected if they were vaccinated with virus heterologous to the challenge strain than if they were vaccinated with homologous virus. Field studies in Thoroughbred racehorses also showed that SRH antibody levels of >/= 150mm2 induced by vaccines containing a European lineage strain are protective against infection with a virus from the same lineage, but that the same or higher antibody levels may not be protective against an American lineage virus. In conclusion, vaccines should contain virus strains representative of both H3N8 subtype lineages to maximise protection against infection.Entities:
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Year: 2004 PMID： 15364463 DOI： 10.1016/j.vaccine.2004.02.048
Source DB: PubMed Journal: Vaccine ISSN： 0264-410X Impact factor: 3.641